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dc.contributor.authorFigueroa, Christopheren_US
dc.date.accessioned2017-09-13T17:50:10Z
dc.date.available2017-09-13T17:50:10Z
dc.date.issued2017
dc.identifier.urihttps://hdl.handle.net/2144/23789
dc.description.abstractGlioblastoma is the most common and most deadly form of brain cancer. With treatment, expected survival time after diagnosis is 15 months and the disease presents with universal morbidity. Current therapies include surgery, radiation, and chemotherapy. One of the current fields of interest for glioblastoma research is in immunotherapy and specifically tumor-associated macrophages (TAMs). Normally, macrophages in an infection or disease state work to degrade and digest pathogens and cancer cells. However, in glioblastoma, current evidence points to TAMs as active tumor-supporters and immunosuppressants. While the field is still relatively in its infancy, much is known about TAMs and their interactions with other immune cells and with cancer cells. This paper elucidates all the different aspects in which TAMs work to support GBM cancer cells and how they encourage tumor growth, progression, and migration. This review consolidates the pertinent information known on how TAMs are recruited, how they contribute to angiogenesis, how they promote tumor migration, how they interact with T cells, and how they become polarized to become tumor-supportive macrophages and suggests approaches for future research given this knowledge.en_US
dc.language.isoen_US
dc.rightsAttribution 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNeurosciencesen_US
dc.titleMacrophages and microglia in glioblastomaen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2017-07-12T22:13:20Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International