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dc.contributor.authorDobyns, Alyssa Christineen_US
dc.date.accessioned2017-09-14T18:24:06Z
dc.date.available2017-09-14T18:24:06Z
dc.date.issued2017
dc.identifier.urihttps://hdl.handle.net/2144/23800
dc.description.abstractBACKGROUND AND AIMS: Obesity is associated with vascular endothelial dysfunction, which predisposes obese persons to cardiovascular disease. Fat loss in obese persons can lead to metabolic improvements that promote improved cardiovascular health and decrease risk of stroke or myocardial infarction. The objective of this study was to assess the potential of weight loss achieved by bariatric surgery to improve endothelial function. METHODS: Patients scheduled to undergo bariatric surgery were prospectively followed. Biochemical analyses and vascular function testing were performed preoperatively and again at 1, 3, 6, and 12 months postoperatively. FMD and NMD were measured to assess macrovascular endothelial function and ∆ hyperemic flow was measured to assess microvascular endothelial function. RESULTS: Patients (n = 375) ages 41.76 ± 12.35 years, with baseline BMI of 45.64 ± 8.36, experienced a weight reduction of 82.07 ± 33.98 lbs the year following surgery. FMD % increased by 1.28 ± 5.49, NMD % by 4.26 ± 6.23, and ∆ hyperemic flow % by 262.1 ± 519.97. All vascular function variables demonstrated a significant increase over time (p < 0.05) with ∆ hyperemic flow % experiencing the most significant change (p < 0.0001). No difference was found in improvement in vascular function between high (>13 µIU/ml) and low (≤13 µIU/ml) baseline plasma insulin groups (p values all > 0.05). CONCLUSIONS: Bariatric surgery was associated with an improvement in macrovascular and microvascular endothelial function. Further analyses is needed to determine which clinical parameters are optimal predictors of improvements in vascular endothelial function after bariatric surgery.en_US
dc.language.isoen_US
dc.subjectMedicineen_US
dc.subjectBariatric surgeryen_US
dc.subjectFMDen_US
dc.subjectEndothelial functionen_US
dc.subjectGastric bypassen_US
dc.subjectHyperemic flowen_US
dc.subjectInsulinen_US
dc.titleThe effect of surgical weight loss interventions on vascular endothelial functionen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2017-07-12T22:13:34Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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