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dc.contributor.authorVaickus, Max Hallen_US
dc.date.accessioned2017-09-25T17:54:09Z
dc.date.available2017-09-25T17:54:09Z
dc.date.issued2017
dc.identifier.urihttps://hdl.handle.net/2144/23995
dc.description.abstractOur murine model of mild traumatic brain injury (mTBI) has shown improved survival after Pseudomonas aeruginosa (Psd) challenge as compared to controls (tail trauma or sham injury). Previous work suggests an mTBI-specific involvement of the neuro-immune axis which augments the innate immune response, increasing survival. Additional factors for the enhanced mTBI survival were explored via microarray analysis of lungs harvested 48 hours post-trauma, the point prior to Psd challenge in our model. At 48 hours post-trauma, mTBI lungs have a number of upregulated ATP synthesis and mitochondrial gene sets. Increased available energy could prime the mTBI lungs, allowing an earlier and more robust response to Psd infection, possibly contributing to the increased mTBI survival. This is supported by increased neutrophil recruitment in the bronchoalveolar lavage of mTBI mice four hours after Psd instillation. Downregulated gene sets related to cellular connections suggest that neutrophils recruited to the lung have an easier extravasation pathway into the air space of mTBI lungs compared to control. Based on genetic and neutrophil recruitment data, it is possible that mTBI creates an energetically prepared and easily accessible lung better tailored for recruiting and allowing entry of neutrophils in response to an infection compared to control.en_US
dc.language.isoen_US
dc.rightsAttribution 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPathologyen_US
dc.subjectMicroarrayen_US
dc.subjectInnate immune systemen_US
dc.subjectTraumatic brain injuryen_US
dc.titleMicroarray analysis of mouse ling examining the augmented pseudomonas aeruginosa clearance following mild traumatic brain injuryen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2017-07-13T22:15:32Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplinePathologyen_US
etd.degree.grantorBoston Universityen_US


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International