Visualizing the role of the SPT4-SPT5 complex in gene transcription
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The Spt4-Spt5 heterodimer complex is one of the key transcription elongation factors for RNA polymerase II, and thus helps to regulate gene expression with either positive or negative stimulation. Spt5 is a part of the NusG family of proteins, and is universally conserved across all three domains of life. This complex is also noted to be involved in many other cellular functions, including chromatin folding, DNA repair, and 5’ cap recruitment; both subunits also play roles in cellular activity when not bound together. However, there is still a great deal of insight to gain about this compound’s functions. This report delves into a variety of previous studies on this complex, summarizing known facts. It will describe how the Spt4-Spt5 complex is actually involved in facilitating transcription for nearly every type of RNA polymerase known so far, and that the secondary characteristics define each homologous structure. The variety of laboratory techniques utilized in these studies will also be noted, and the functionality of this versatile complex will be conveyed as known.