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  • A transitional opioid program to engage hospitalized drug users 

    Shanahan, C. W.; Beers, D.; Alford, D. P.; Brigandi, E.; Samet, J. H. (J Gen Intern Med., 2010-08)
    BACKGROUND: Many opioid-dependent patients do not receive care for addiction issues when hospitalized for other medical problems. Based on 3 years of clinical practice, we report the Transitional Opioid Program (TOP) ...
  • Inhibitory Effects of Robo2 on Nephrin: A Crosstalk between Positive and Negative Signals Regulating Podocyte Structure 

    Fan, Xueping; Li, Qinggang; Pisarek-Horowitz, Anna; Rasouly, Hila Milo; Wang, Xiangling; Bonegio, Ramon G.; Wang, Hang; McLaughlin, Margaret; Mangos, Steve; Kalluri, Raghu; Holzman, Lawrence B.; Drummond, Iain A.; Brown, Dennis; Salant, David J.; Lu, Weining (Elsevier, 2012-07-26)
    Robo2 is the cell surface receptor for the repulsive guidance cue Slit and is involved in axon guidance and neuronal migration. Nephrin is a podocyte slit- diaphragm protein that functions in the kidney glomerular filtration ...
  • Noninvasive Assessment of Antenatal Hydronephrosis in Mice Reveals a Critical Role for Robo2 in Maintaining Anti-Reflux Mechanism 

    Wang, Hang; Li, Qinggang; Liu, Juan; Mendelsohn, Cathy; Salant, David J.; Lu, Weining (PLoS ONE, 2011-09-20)
    Antenatal hydronephrosis and vesicoureteral reflux (VUR) are common renal tract birth defects. We recently showed that disruption of the Robo2 gene is associated with VUR in humans and antenatal hydronephrosis in knockout ...
  • Direct Assessment of Cumulative Aryl Hydrocarbon Receptor Agonist Activity in Sera from Experimentally Exposed Mice and Environmentally Exposed Humans 

    Schlezinger, Jennifer J.; Bernard, Pamela L.; Haas, Amelia; Grandjean, Philippe; Weihe, Pal; Sherr, David H. (National Institute of Environmental Health SciencesBoston University Center for Interdisciplinary Research in Environmental Exposures and Health; National Institutes of Health (P01 ES11624, R01 ES006086, R01 ES011681, R01 ES012199); Superfund (2P42ES007381-15); United States Environmental Protection Agency (RD-83075801-0), 2010-05)
    BACKGROUND. Aryl hydrocarbon receptor (AhR) ligands adversely affect many biological processes. However, assessment of the significance of human exposures is hampered by an incomplete understanding of how complex mixtures ...
  • The Epidemiology and Management of Severe Hypertension 

    Borzecki, A. M.; Kader, B.; Berlowitz, D. R. (Nature Publishing Group, 2009-05-14)
    Hypertension guidelines stress that patients with severe hypertension (systolic blood pressure (BP)⩾180 or diastolic BP⩾110mmHg) require multiple drugs to achieve control and should have close follow-up to prevent adverse ...
  • Video Decision Support Tool for Advance Care Planning in Dementia: Randomised Controlled Trial 

    Volandes, Angelo E.; Paasche-Orlow, Michael K.; Barry, Michael J.; Gillick, Muriel R.; Minaker, Kenneth L.; Chang, Yuchiao; Cook, E. Francis; Abbo, Elmer D.; El-Jawahri, Areej; Mitchell, Susan L. (BMJ Publishing Group Ltd., 2009-5-28)
    Objective To evaluate the effect of a video decision support tool on the preferences for future medical care in older people if they develop advanced dementia, and the stability of those preferences after six weeks. Design ...
  • Black Carbon Exposure, Oxidative Stress Genes, and Blood Pressure in a Repeated-Measures Study 

    Mordukhovich, Irina; Wilker, Elissa; Suh, Helen; Wright, Robert; Sparrow, David; Vokonas, Pantel S.; Schwartz, Joel (National Institute of Environmental Health Sciences, 2009-11)
    BACKGROUND. Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies ...
  • Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study 

    Perlstein, Todd; Weuve, Jennifer; Schwartz, Joel; Sparrow, David; Wright, Robert; Litonjua, Augusto; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007-12)
    BACKGROUND. Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote ...
  • SIEGE: Smoking Induced Epithelial Gene Expression Database 

    Shah, Vishal; Sridhar, Sriram; Beane, Jennifer; Brody, Jerome S.; Spira, Avrum (Oxford University Press, 2004-12-17)
    The SIEGE (Smoking Induced Epithelial Gene Expression) database is a clinical resource for compiling and analyzing gene expression data from epithelial cells of the human intra-thoracic airway. This database supports a ...
  • Skewed X-Chromosomal Inactivation Impacts T Regulatory Cell Function in Systemic Sclerosis 

    Broen, J. C. A.; Wolvers-Tettero, I. L. M.; Geurts-van Bon, L.; Vonk, M. C.; Coenen, M. J. H.; Lafyatis, R.; Radstake, T. R. D. J.; Langerak, A. W. (BioMed Central, 2010-11-25)

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