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  • A transitional opioid program to engage hospitalized drug users 

    Shanahan, C. W.; Beers, D.; Alford, D. P.; Brigandi, E.; Samet, J. H. (J Gen Intern Med., 2010-08)
    BACKGROUND: Many opioid-dependent patients do not receive care for addiction issues when hospitalized for other medical problems. Based on 3 years of clinical practice, we report the Transitional Opioid Program (TOP) ...
  • Inhibitory Effects of Robo2 on Nephrin: A Crosstalk between Positive and Negative Signals Regulating Podocyte Structure 

    Fan, Xueping; Li, Qinggang; Pisarek-Horowitz, Anna; Rasouly, Hila Milo; Wang, Xiangling; Bonegio, Ramon G.; Wang, Hang; McLaughlin, Margaret; Mangos, Steve; Kalluri, Raghu; Holzman, Lawrence B.; Drummond, Iain A.; Brown, Dennis; Salant, David J.; Lu, Weining (Elsevier, 2012-07-26)
    Robo2 is the cell surface receptor for the repulsive guidance cue Slit and is involved in axon guidance and neuronal migration. Nephrin is a podocyte slit- diaphragm protein that functions in the kidney glomerular filtration ...
  • Noninvasive Assessment of Antenatal Hydronephrosis in Mice Reveals a Critical Role for Robo2 in Maintaining Anti-Reflux Mechanism 

    Wang, Hang; Li, Qinggang; Liu, Juan; Mendelsohn, Cathy; Salant, David J.; Lu, Weining (PLoS ONE, 2011-09-20)
    Antenatal hydronephrosis and vesicoureteral reflux (VUR) are common renal tract birth defects. We recently showed that disruption of the Robo2 gene is associated with VUR in humans and antenatal hydronephrosis in knockout ...
  • Evaluation of the Sustainability of an Intervention to Increase HIV Testing 

    Goetz, Matthew Bidwell; Hoang, Tuyen; Henry, S. Randal; Knapp, Herschel; Anaya, Henry D.; Gifford, Allen L.; Asch, Steven M. (Springer-Verlag, 2009-10-2)
    BACKGROUND Sustainability—the routinization and institutionalization of processes that improve the quality of healthcare—is difficult to achieve and not often studied. OBJECTIVE To evaluate the sustainability of increased ...
  • Large-Scale Mapping and Validation of Escherichia coli Transcriptional Regulation from a Compendium of Expression Profiles 

    Faith, Jeremiah J.; Hayete, Boris; Thaden, Joshua T.; Mogno, Ilaria; Wierzbowski, Jamey; Cottarel, Guillaume; Kasif, Simon; Collins, James J.; Gardner, Timothy S. (Public Library of Science, 2007-1-9)
    Machine learning approaches offer the potential to systematically identify transcriptional regulatory interactions from a compendium of microarray expression profiles. However, experimental validation of the performance ...
  • A Case-Only Analysis of the Interaction between N-Acetyltransferase 2 Haplotypes and Tobacco Smoke on Breast Cancer Etiology 

    Lash, Timothy L.; Bradbury, Brian D.; Wilk, Jemma B.; Aschengrau, Ann (BioMed Central, 2005-3-21)
    INTRODUCTION. N-acetyltransferase 2 is a polymorphic enzyme in humans. Women who possess homozygous polymorphic alleles have a slower rate of metabolic activation of aryl aromatic amines, one of the constituents of tobacco ...
  • Protein Kinase A Binds and Activates Heat Shock Factor 1 

    Murshid, Ayesha; Chou, Shiuh-Dih; Prince, Thomas; Zhang, Yue; Bharti, Ajit; Calderwood, Stuart K. (Public Library of Science, 2010-11-9)
    BACKGROUND. Many inducible transcription factors are regulated through batteries of posttranslational modifications that couple their activity to inducing stimuli. We have studied such regulation of Heat Shock Factor 1 ...
  • AGT M235T Genotype/Anxiety Interaction and Gender in the HyperGEN Study 

    Knox, Sarah S.; Guo, Xinxin; Zhang, Yuqing; Weidner, G.; Williams, Scott; Ellison, R. Curtis (Public Library of Science, 2010-10-13)
    BACKGROUND. Both anxiety and elevated heart rate (HR) have been implicated in the development of hypertension. The HyperGen cohort, consisting of siblings with severe and mild hypertension, an age-matched random sample of ...
  • Acyl Peptide Hydrolase Degrades Monomeric and Oligomeric Amyloid-Beta Peptide 

    Yamin, Rina; Zhao, Cheng; O'Connor, Peter B.; McKee, Ann C.; Abraham, Carmela R. (BioMed Central, 2009-7-23)
    BACKGROUND The abnormal accumulation of amyloid-beta peptide is believed to cause malfunctioning of neurons in the Alzheimer's disease brain. Amyloid-beta exists in different assembly forms in the aging mammalian brain ...
  • Association between Radiographic Features of Knee Osteoarthritis and Pain: Results from Two Cohort Studies 

    Neogi, Tuhina; Felson, David; Niu, Jingbo; Nevitt, Michael; Lewis, Cora E; Aliabadi, Piran; Sack, Burt; Torner, James; Bradley, Lawrence; Zhang, Yuqing (BMJ Publishing Group Ltd., 2009-8-21)
    Objective To examine the relation of radiographic features of osteoarthritis to knee pain in people with knees discordant for knee pain in two cohorts. Design Within person, knee matched, case-control study. Setting and ...

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