URI: http://hdl.handle.net/2144/2428

Recently Added

  • A transitional opioid program to engage hospitalized drug users 

    Shanahan, C.W.; Beers, D.; Alford, D.P.; Brigandi, E.; Samet, J.H. (J Gen Intern Med., 2010-08)
    BACKGROUND: Many opioid-dependent patients do not receive care for addiction issues when hospitalized for other medical problems. Based on 3 years of clinical practice, we report the Transitional Opioid Program (TOP) ...
  • Noninvasive Assessment of Antenatal Hydronephrosis in Mice Reveals a Critical Role for Robo2 in Maintaining Anti-Reflux Mechanism 

    Wang, Hang; Li, Qinggang; Liu, Juan; Mendelsohn, Cathy; Salant, David J.; Lu, Weining (PLoS ONE, 2011-09-20)
    Antenatal hydronephrosis and vesicoureteral reflux (VUR) are common renal tract birth defects. We recently showed that disruption of the Robo2 gene is associated with VUR in humans and antenatal hydronephrosis in knockout ...
  • Inhibitory Effects of Robo2 on Nephrin: A Crosstalk between Positive and Negative Signals Regulating Podocyte Structure 

    Fan, Xueping; Li, Qinggang; Pisarek-Horowitz, Anna; Rasouly, Hila Milo; Wang, Xiangling; Bonegio, Ramon G.; Wang, Hang; McLaughlin, Margaret; Mangos, Steve; Kalluri, Raghu; Holzman, Lawrence B.; Drummond, Iain A.; Brown, Dennis; Salant, David J.; Lu, Weining (Elsevier, 2012-07-26)
    Robo2 is the cell surface receptor for the repulsive guidance cue Slit and is involved in axon guidance and neuronal migration. Nephrin is a podocyte slit- diaphragm protein that functions in the kidney glomerular filtration ...
  • Bosentan Treatment of Digital Ulcers Related to Systemic Sclerosis: Results from the RAPIDS-2 Randomised, Double-Blind, Placebo-Controlled Trial 

    Matucci-Cerinic, Marco; Denton, Christopher P.; Furst, Daniel E.; Mayes, Maureen D.; Hsu, Vivien M.; Carpentier, Patrick; Wigley, Fredrick M.; Black, Carol M.; Fessler, Barri J.; Merkel, Peter A.; Pope, Janet E.; Sweiss, Nadera J.; Doyle, Mittie K.; Hellmich, Bernhard; Medsger, Thomas A.; Morganti, Adele; Kramer, Fabrice; Korn, Joseph H.; Seibold, James R. (BMJ Group, 2010-9-28)
    OBJECTIVES. Ischaemic digital ulcers (DUs) are common in patients with systemic sclerosis (SSc) and are a cause of disease-related morbidity. In an earlier trial, treatment with bosentan, an oral endothelin receptor ...
  • DNA-like Class R Inhibitory Oligonucleotides (INH-ODNs) Preferentially Block Autoantigen-Induced B-Cell and Dendritic Cell Activation in Vitro and Autoantibody Production in Lupus-Prone MRL-Faslpr/lpr Mice in Vivo 

    Lenert, Petar; Yasuda, Kei; Busconi, Liliana; Nelson, Patrice; Fleenor, Courtney; Ratnabalasuriar, Radhika S.; Nagy, Peter L.; Ashman, Robert F.; Rifkin, Ian R.; Marshak-Rothstein, Ann (BioMed Central, 2009-5-28)
    INTRODUCTION. B cells have many different roles in systemic lupus erythematosus (SLE), ranging from autoantigen recognition and processing to effector functions (for example, autoantibody and cytokine secretion). Recent ...
  • A Functional Difficulty and Functional Pain Instrument for Hip and Knee Osteoarthritis 

    Jette, Alan M.; McDonough, Christine M.; Ni, Pengsheng; Haley, Stephen M.; Hambleton, Ronald K.; Olarsch, Sippy; Hunter, David J.; Kim, Young-jo; Felson, David T. (BioMed Central, 2009-7-9)
    INTRODUCTION. The objectives of this study were to develop a functional outcome instrument for hip and knee osteoarthritis research (OA-FUNCTION-CAT) using item response theory (IRT) and computer adaptive test (CAT) methods ...
  • Capillary Regeneration in Scleroderma: Stem Cell Therapy Reverses Phenotype? 

    Fleming, Jo N.; Nash, Richard A.; McLeod, D. O.; Fiorentino, David F.; Shulman, Howard M.; Connolly, M. Kari; Molitor, Jerry A.; Henstorf, Gretchen; Lafyatis, Robert; Pritchard, David K.; Adams, Lawrence D.; Furst, Daniel E.; Schwartz, Stephen M. (Public Library of Science, 2008-1-16)
    BACKGROUND. Scleroderma is an autoimmune disease with a characteristic vascular pathology. The vasculopathy associated with scleroderma is one of the major contributors to the clinical manifestations of the disease. ...
  • RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans 

    Sebastiani, Paola; Montano, Monty; Puca, Annibale; Solovieff, Nadia; Kojima, Toshio; Wang, Meng C.; Melista, Efthymia; Meltzer, Micah; Fischer, Sylvia E. J.; Andersen, Stacy; Hartley, Stephen H.; Sedgewick, Amanda; Arai, Yasumichi; Bergman, Aviv; Barzilai, Nir; Terry, Dellara F.; Riva, Alberto; Anselmi, Chiara Viviani; Malovini, Alberto; Kitamoto, Aya; Sawabe, Motoji; Arai, Tomio; Gondo, Yasuyuki; Steinberg, Martin H.; Hirose, Nobuyoshi; Atzmon, Gil; Ruvkun, Gary; Baldwin, Clinton T.; Perls, Thomas T. (Public Library of Science, 2009-12-14)
    BACKGROUND. The strong familiality of living to extreme ages suggests that human longevity is genetically regulated. The majority of genes found thus far to be associated with longevity primarily function in lipoprotein ...
  • Leg-Length Inequality Is not Associated with Greater Trochanteric Pain Syndrome 

    Segal, Neil A.; Harvey, William; Felson, David T.; Yang, Mei; Torner, James C.; Curtis, Jeffrey R.; Nevitt, Michael C. (BioMed Central, 2008-5-29)
    INTRODUCTION. Greater trochanteric pain syndrome (GTPS) is a common condition, the pathogenesis of which is incompletely understood. Although leg-length inequality has been suggested as a potential risk factor for GTPS, ...
  • Cartilage Markers and Their Association with Cartilage Loss on Magnetic Resonance Imaging in Knee Osteoarthritis: The Boston Osteoarthritis Knee Study 

    Hunter, David J.; Li, Jiang; LaValley, Michael; Bauer, Doug C.; Nevitt, Michael; DeGroot, Jeroen; Poole, Robin; Eyre, David; Guermazi, Ali; Gale, Dan; Felson, David T. (BioMed Central, 2007-10-24)
    We used data from a longitudinal observation study to determine whether markers of cartilage turnover could serve as predictors of cartilage loss on magnetic resonance imaging (MRI). We conducted a study of data from the ...
  • Mutations in the Paralogous Human α-globin Genes Yielding Identical Hemoglobin Variants 

    Moradkhani, Kamran; Préhu, Claude; Old, John; Henderson, Shirley; Balamitsa, Vera; Luo, Hong-Yuan; Poon, Man-Chiu; Chui, David H. K.; Wajcman, Henri; Patrinos, George P. (Springer-Verlag, 2008-10-16)
    The human α-globin genes are paralogues, sharing a high degree of DNA sequence similarity and producing an identical α-globin chain. Over half of the α-globin structural variants reported to date are only characterized at ...
  • Evaluation of Association of HNF1B Variants with Diverse Cancers: Collaborative Analysis of Data from 19 Genome-Wide Association Studies 

    Elliott, Katherine S.; Zeggini, Eleftheria; McCarthy, Mark I.; Gudmundsson, Julius; Sulem, Patrick; Stacey, Simon N.; Thorlacius, Steinunn; Amundadottir, Laufey; Grönberg, Henrik; Xu, Jianfeng; Gaborieau, Valerie; Eeles, Rosalind A.; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Muir, Kenneth; Hwang, Shih-Jen; Spitz, Margaret R.; Zanke, Brent; Carvajal-Carmona, Luis; Brown, Kevin M.; Mann, Graham J.; Hayward, Nicholas K.; Macgregor, Stuart; Tomlinson, Ian P. M.; Lemire, Mathieu; Amos, Christopher I.; Murabito, Joanne M.; Isaacs, William B.; Easton, Douglas F.; Brennan, Paul; Barkardottir, Rosa B.; Gudbjartsson, Daniel F.; Rafnar, Thorunn; Hunter, David J.; Chanock, Stephen J.; Stefansson, Kari; Ioannidis, John P. A.; Hopper, John L.; Aitken, Joanne F.; Kefford, Richard F.; Giles, Graham G.; Armstrong, Bruce K. (Public Library of Science, 2010-5-28)
    BACKGROUND. Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk. We aimed to identify whether these variants may ...
  • Genetic Analyses of Longitudinal Phenotype Data: A Comparison of Univariate Methods and a Multivariate Approach 

    Yang, Qiong; Chazaro, Irmarie; Cui, Jing; Guo, Chao-Yu; Demissie, Serkalem; Larson, Martin; Atwood, Larry D.; Cupples, L. Adrienne; DeStefano, Anita L. (BioMed Central, 2003-12-31)
    BACKGROUND. We explored three approaches to heritability and linkage analyses of longitudinal total cholesterol levels (CHOL) in the Genetic Analysis Workshop 13 simulated data without knowing the answers. The first two ...
  • Availability and Utilization of Malaria Prevention Strategies in Pregnancy in Eastern India 

    Wylie, Blair J; Hashmi, Ahmar H.; Singh, Neeru; Singh, Mrigendra P.; Tuchman, Jordan; Hussain, Mobassir; Sabin, Lora; Yeboah-Antwi, Kojo; Banerjee, Camellia; Brooks, Mohamad I.; Desai, Meghna; Udhayakumar, Venkatachalam; MacLeod, William B.; Dash, Aditya P.; Hamer, Davidson H. (BioMed Central, 2010-9-17)
    BACKGROUND. Malaria in pregnancy in India, as elsewhere, is responsible for maternal anemia and adverse pregnancy outcomes such as low birth weight and preterm birth. It is not known whether prevention and treatment ...
  • A Multilevel Intervention to Promote Colorectal Cancer Screening among Community Health Center Patients: Results of a Pilot Study 

    Lasser, Karen E.; Murillo, Jennifer; Medlin, Elizabeth; Lisboa, Sandra; Valley-Shah, Lisa; Fletcher, Robert H.; Emmons, Karen M.; Ayanian, John Z. (BioMed Central, 2009-5-29)
    BACKGROUND. Colorectal cancer screening rates are low among poor and disadvantaged patients. Patient navigation has been shown to increase breast and cervical cancer screening rates, but few studies have looked at the ...
  • Migraine, Fibromyalgia, and Depression among People with IBS: A Prevalence Study 

    Cole, J. Alexander; Rothman, Kenneth J.; Cabral, Howard J.; Zhang, Yuqing; Farraye, Francis A. (BioMed Central, 2006-9-28)
    BACKGROUND. Case descriptions suggest IBS patients are more likely to have other disorders, including migraine, fibromyalgia, and depression. We sought to examine the prevalence of these conditions in cohorts of people ...
  • Alterations in Gene Expression in T1α Null Lung: A Model of Deficient Alveolar Sac Development 

    Millien, Guetchyn; Spira, Avrum; Hinds, Anne; Wang, Junling; Williams, Mary C; Ramirez, Maria I (BioMed Central, 2006-7-25)
    BACKGROUND. Development of lung alveolar sacs of normal structure and size at late gestation is necessary for the gas exchange process that sustains respiration at birth. Mice lacking the lung differentiation gene T1α ...
  • Empirically Derived Phenotypic Subgroups – Qualitative and Quantitative Trait Analyses 

    Wilcox, Marsha A.; Wyszynski, Diego F.; Panhuysen, Carolien I.; Ma, Qianli; Yip, Agustin; Farrell, John; Farrer, Lindsay A. (BioMed Central, 2003-12-31)
    BACKGROUND. The Framingham Heart Study has contributed a great deal to advances in medicine. Most of the phenotypes investigated have been univariate traits (quantitative or qualitative). The aims of this study are to ...
  • Search for Genetic Factors Predisposing to Atherogenic Dyslipidemia 

    Yip, Agustin G.; Ma, Qianli; Wilcox, Marsha; Panhuysen, Carolien I.; Farrell, John; Farrer, Lindsay A.; Wyszynski, Diego F. (BioMed Central, 2003-12-31)
    BACKGROUND. Atherogenic dyslipidemia (AD) is a common feature in persons with premature coronary heart disease. While several linkage studies have been carried out to dissect the genetic etiology of lipid levels, few have ...
  • Genome-Wide Screen for Heavy Alcohol Consumption 

    Wyszynski, Diego F.; Panhuysen, Carolien I.; Ma, Qianli; Yip, Agustin G.; Wilcox, Marsha; Erlich, Porat; Farrer, Lindsay A. (BioMed Central, 2003-12-31)
    BACKGROUND. To find specific genes predisposing to heavy alcohol consumption (self-reported consumption of 24 grams or more of alcohol per day among men and 12 grams or more among women), we studied 330 families collected ...

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