URI: http://hdl.handle.net/2144/2435

Recently Added

  • A Genome-Wide Association Study of Hypertension and Blood Pressure in African Americans 

    Adeyemo, Adebowale; Gerry, Norman; Chen, Guanjie; Herbert, Alan; Doumatey, Ayo; Huang, Hanxia; Zhou, Jie; Lashley, Kerrie; Chen, Yuanxiu; Christman, Michael; Rotimi, Charles (Public Library of Science, 2009-7-17)
    The evidence for the existence of genetic susceptibility variants for the common form of hypertension ("essential hypertension") remains weak and inconsistent. We sought genetic variants underlying blood pressure (BP) by ...
  • Molecular Weight Assessment of Proteins in Total Proteome Profiles using 1D-PAGE and LC/MS/MS 

    Ahmad, Q. Rushdy; Nguyen, Dat H.; Wingerd, Mark A.; Church, George M.; Steffen, Martin A. (BioMed Central, 2005-6-8)
    BACKGROUND. The observed molecular weight of a protein on a 1D polyacrylamide gel can provide meaningful insight into its biological function. Differences between a protein's observed molecular weight and that predicted ...
  • Integration of Relational and Hierarchical Network Information for Protein Function Prediction 

    Jiang, Xiaoyu; Nariai, Naoki; Steffen, Martin; Kasif, Simon; Kolaczyk, Eric D (BioMed Central, 2008-8-22)
    BACKGROUND. In the current climate of high-throughput computational biology, the inference of a protein's function from related measurements, such as protein-protein interaction relations, has become a canonical task. Most ...
  • Transferability and Fine-Mapping of Genome-Wide Associated Loci for Adult Height across Human Populations 

    Shriner, Daniel; Adeyemo, Adebowale; Gerry, Norman P.; Herbert, Alan; Chen, Guanjie; Doumatey, Ayo; Huang, Hanxia; Zhou, Jie; Christman, Michael F.; Rotimi, Charles N. (Public Library of Science, 2009-12-22)
    Human height is the prototypical polygenic quantitative trait. Recently, several genetic variants influencing adult height were identified, primarily in individuals of East Asian (Chinese Han or Korean) or European ancestry. ...
  • Telomere Disruption Results in Non-Random Formation of De Novo Dicentric Chromosomes Involving Acrocentric Human Chromosomes 

    Stimpson, Kaitlin M.; Song, Ihn Young; Jauch, Anna; Holtgreve-Grez, Heidi; Hayden, Karen E.; Bridger, Joanna M.; Sullivan, Beth A. (Public Library of Science, 2010-8-12)
    Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly ...
  • Evidence for a "Wattle and Daub" Model of the Cyst Wall of Entamoeba 

    Chatterjee, Anirban; Ghosh, Sudip K.; Jang, Ken; Bullitt, Esther; Moore, Landon; Robbins, Phillips W.; Samuelson, John (Public Library of Science, 2009-7-3)
    The cyst wall of Entamoeba invadens (Ei), a model for the human pathogen Entamoeba histolytica, is composed of fibrils of chitin and three chitin-binding lectins called Jacob, Jessie3, and chitinase. Here we show chitin, ...
  • Cofilin Activation in Peripheral CD4 T Cells of HIV-1 Infected Patients: A Pilot Study 

    Wu, Yuntao; Yoder, Alyson; Yu, Dongyang; Wang, Weifeng; Liu, Juan; Barrett, Tracey; Wheeler, David; Schlauch, Karen (BioMed Central, 2008-10-17)
    Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form. ...
  • Previously Unidentified Changes in Renal Cell Carcinoma Gene Expression Identified by Parametric Analysis of Microarray Data 

    Lenburg, Marc E.; Liou, Louis S.; Gerry, Norman P.; Frampton, Garrett M.; Cohen, Herbert T.; Christman, Michael F. (BioMed Central, 2003-11-27)
    BACKGROUND. Renal cell carcinoma is a common malignancy that often presents as a metastatic-disease for which there are no effective treatments. To gain insights into the mechanism of renal cell carcinogenesis, a number ...
  • Reversible and Permanent Effects of Tobacco Smoke Exposure on Airway Epithelial Gene Expression 

    Beane, Jennifer; Sebastiani, Paola; Liu, Gang; Brody, Jerome S.; Lenburg, Marc E.; Spira, Avrum (BioMed Central, 2007-09-25)
    Oligonucleotide microarray analysis revealed 175 genes that are differentially expressed in large airway epithelial cells of people who currently smoke compared with those who never smoked, with 28 classified as irreversible, ...
  • Lack of Association between Angiotensin-Converting Enzyme and Dementia of the Alzheimer's Type in an Elderly Arab Population in Wadi Ara, Israel 

    Bowirrat, Abdalla; Cui, Jing; Waraska, Kristin; Friedland, Robert P.; Oscar-Berman, Marlene; Farrer, Lindsay A.; Korczyn, Amos; Baldwin, Clinton T. (Dove Medical Press, 2005)
    The angiotensin-converting enzyme (ACE), a protease involved in blood pressure regulation, has been implicated as an important candidate gene for Alzheimer's disease (AD). This study investigated whether the ACE gene ...
  • Development of Admixture Mapping Panels for African Americans from Commercial High-Density SNP Arrays 

    Chen, Guanjie; Shriner, Daniel; Zhou, Jie; Doumatey, Ayo; Huang, Hanxia; Gerry, Norman P.; Herbert, Alan; Christman, Michael F.; Chen, Yuanxiu; Dunston, Georgia M.; Faruque, Mezbah U.; Rotimi, Charles N.; Adeyemo, Adebowale (BioMed Central, 2010-7-5)
    BACKGROUND: Admixture mapping is a powerful approach for identifying genetic variants involved in human disease that exploits the unique genomic structure in recently admixed populations. To use existing published panels ...
  • Tissue-Specific mRNA Expression Profiling in Grape Berry Tissues 

    Grimplet, Jerome; Deluc, Laurent G.; Tillett, Richard L.; Wheatley, Matthew D.; Schlauch, Karen A.; Cramer, Grant R.; Cushman, John C. (BioMed Central, 2007-6-21)
    BACKGROUND: Berries of grape (Vitis vinifera) contain three major tissue types (skin, pulp and seed) all of which contribute to the aroma, color, and flavor characters of wine. The pericarp, which is composed of the exocarp ...
  • Transcriptomic and Metabolite Analyses of Cabernet Sauvignon Grape Berry Development 

    Deluc, Laurent G.; Grimplet, Jérôme; Wheatley, Matthew D.; Tillett, Richard L.; Quilici, David R.; Osborne, Craig; Schooley, David A.; Schlauch, Karen A.; Cushman, John C; Cramer, Grant R. (BioMed Central, 2007-11-22)
    BACKGROUND: Grape berry development is a dynamic process that involves a complex series of molecular genetic and biochemical changes divided into three major phases. During initial berry growth (Phase I), berry size increases ...
  • Genetic Analysis of the Spindle Checkpoint Genes san-1, mdf-2, bub-3 and the CENP-F Homologues hcp-1 and hcp-2 in Caenorhabditis Elegans 

    Hajeri, Vinita A; Stewart, Anil M; Moore, Landon L; Padilla, Pamela A (BioMed Central, 2008-2-4)
    BACKGROUND: The spindle checkpoint delays the onset of anaphase until all sister chromatids are aligned properly at the metaphase plate. To investigate the role san-1, the MAD3 homologue, has in Caenorhabditis elegans ...
  • Genetic mModifiers of Hb E/β0 Thalassemia Identified by a Two-Stage Genome-Wide Association Study 

    Sherva, Richard; Sripichai, Orapan; Abel, Kenneth; Ma, Qianli; Whitacre, Johanna; Angkachatchai, Vach; Makarasara, Wattanan; Winichagoon, Pranee; Svasti, Saovaros; Fucharoen, Suthat; Braun, Andreas; Farrer, Lindsay A. (BioMed Central, 2010-3-30)
    BACKGROUND: Patients with Hb E/β0 thalassemia display remarkable variability in disease severity. To identify genetic modifiers influencing disease severity, we conducted a two-stage genome scan in groups of 207 mild and ...
  • Smoking-Induced Gene Expression Changes in the Bronchial Airway Are Reflected in Nasal and Buccal Epithelium 

    Sridhar, Sriram; Schembri, Frank; Zeskind, Julie; Shah, Vishal; Gustafson, Adam M.; Steiling, Katrina; Liu, Gang; Dumas, Yves-Martine; Zhang, Xiaohui; Brody, Jerome S.; Lenburg, Marc E.; Spira, Avrum (BioMed Central, 2008-5-30)
    BACKGROUND: Cigarette smoking is a leading cause of preventable death and a significant cause of lung cancer and chronic obstructive pulmonary disease. Prior studies have demonstrated that smoking creates a field of molecular ...
  • Nonsteroidal Anti-Inflammatory Drug Use and Alzheimer's Disease Risk: The MIRAGE Study 

    Yip, Agustín G.; Green, Robert C.; Huyck, Matthew; Cupples, L. Adrienne; Farrer, Lindsay A. (BioMed Central, 2005-1-12)
    BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAID) use may protect against Alzheimer's disease (AD) risk. We sought examine the association between NSAID use and risk of AD, and potential effect modification by APOE-ε4 ...