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  • Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs 

    Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Kanara, Iphigenia; Mavrakis, Anastasios N.; Pernokas, Julie; Pernokas, Mark; Pinkert, Carl A.; Powers, Whitney R.; Sampani, Konstantina; Steliou, Kosta; Vavvas, Demetrios G.; Zamboni, Robert J.; Kodukula, Krishna; Chen, Xiaohong (Mary Ann Liebert, Inc., 2020)
    In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination ...
  • Epigenetic treatment of dermatologic disorders 

    Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Kanara, Iphigenia; Pinkert, Carl A.; Powers, Whitney R.; Sampani, Konstantina; Steliou, Kosta; Vavvas, Demetrios G.; Kodukula, Krishna; Zamboni, Robert J. (Wiley, 2019-09)
    Healthy skin protects us against a multitude of insults but injured or maladapted skin can lead to infection, inflammation or worse. Fortunately, naturally occurring bioactive products, many commonly found in olive oil and ...
  • Automated identification of neurons and their locations 

    Inglis, Andrew; Cruz, Luis; Roe, Dan L.; Stanley, Harry Eugene; Rosene, Douglas L.; Urbanc, Brigita (WILEY-BLACKWELL, 2008-06-01)
    Individual locations of many neuronal cell bodies (>10^4) are needed to enable statistically significant measurements of spatial organization within the brain such as nearest‐neighbour and microcolumnarity measurements. ...
  • Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21 

    Magnain, Caroline; Augustinack, Jean C.; Tirrell, Lee; Fogarty, Morgan; Frosch, Matthew P.; Boas, David; Fischl, Bruce; Rockland, Kathleen S. (Springer Science and Business Media LLC, 2019-01)
    Optical coherence tomography is an optical technique that uses backscattered light to highlight intrinsic structure, and when applied to brain tissue, it can resolve cortical layers and fiber bundles. Optical coherence ...
  • Cognitive-Behavior Therapy (CBT) for Panic Disorder: Relationship of Anxiety and Depression Comorbidity with Treatment Outcome 

    Allen, Laura B.; White, Kamila S.; Barlow, David H.; Shear, M. Katherine; Gorman, Jack M.; Woods, Scott W. (Springer US, 2009-7-24)
    Research evaluating the relationship of comorbidity to treatment outcome for panic disorder has produced mixed results. The current study examined the relationship of comorbid depression and anxiety to treatment outcome ...
  • The Circadian System Is a Target and Modulator of Prenatal Cocaine Effects 

    Shang, Eva H.; Zhdanova, Irina V. (Public Library of Science, 2007-7-11)
    BACKGROUND. Prenatal exposure to cocaine can be deleterious to embryonic brain development, but the results in humans remain controversial, the mechanisms involved are not well understood and effective therapies are yet ...
  • Parallel Driving and Modulatory Pathways Link the Prefrontal Cortex and Thalamus 

    Zikopoulos, Basilis; Barbas, Helen (Public Library of Science, 2007-9-5)
    Pathways linking the thalamus and cortex mediate our daily shifts from states of attention to quiet rest, or sleep, yet little is known about their architecture in high-order neural systems associated with cognition, emotion ...
  • Activation instead of Blocking Mesolimbic Dopaminergic Reward Circuitry Is a Preferred Modality in the Long Term Treatment of Reward Deficiency Syndrome (RDS): A Commentary 

    Blum, Kenneth; Chen, Amanda Lih Chuan; Chen, Thomas J. H.; Braverman, Eric R.; Reinking, Jeffrey; Blum, Seth H.; Cassel, Kimberly; Downs, Bernard W.; Waite, Roger L.; Williams, Lonna; Prihoda, Thomas J.; Kerner, Mallory M.; Palomo, Tomas; Comings, David E.; Tung, Howard; Rhoades, Patrick; Oscar-Berman, Marlene (BioMed Central, 2008-11-12)
    BACKGROUND AND HYPOTHESIS. Based on neurochemical and genetic evidence, we suggest that both prevention and treatment of multiple addictions, such as dependence to alcohol, nicotine and glucose, should involve a biphasic ...
  • Effects of tamoxifen on vaginal blood flow and epithelial morphology in the rat 

    Kim, Noel N.; Stankovic, Miljan; Armagan, Abdullah; Cushman, Tulay T.; Goldstein, Irwin; Traish, Abdulmaged M. (BioMed Central, 2006-9-13)
    BACKGROUND. Tamoxifen, a selective estrogen receptor modulator with both estrogenic and anti-estrogenic activity, is widely used as adjuvant therapy in breast cancer patients. Treatment with tamoxifen is associated with ...
  • Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers 

    Kim, Noel N.; Stankovic, Miljan; Cushman, Tulay T.; Goldstein, Irwin; Munarriz, Ricardo; Traish, Abdulmaged M. (BioMed Central, 2006-5-30)
    BACKGROUND. Diabetes is associated with declining sexual function in women. However, the effects of diabetes on genital tissue structure, innervation and function remains poorly characterized. In control and streptozotocin-treated ...

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