URI: http://hdl.handle.net/2144/2446

Recently Added

  • The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide 

    Soscia, Stephanie J.; Kirby, James E.; Washicosky, Kevin J.; Tucker, Stephanie M.; Ingelsson, Martin; Hyman, Bradley; Burton, Mark A.; Goldstein, Lee E.; Duong, Scott; Tanzi, Rudolph E.; Moir, Robert D. (Public Library of Science, 2010-3-3)
    BACKGROUND. The amyloid β-protein (Aβ) is believed to be the key mediator of Alzheimer's disease (AD) pathology. Aβ is most often characterized as an incidental catabolic byproduct that lacks a normal physiological role. ...
  • Automated MRI Measures Identify Individuals with Mild Cognitive Impairment and Alzheimer's Disease* 

    Desikan, Rahul S.; Cabral, Howard J.; Hess, Christopher P.; Dillon, William P.; Glastonbury, Christine M.; Weiner, Michael W.; Schmansky, Nicholas J.; Greve, Douglas N.; Salat, David H.; Buckner, Randy L.; Fischl, Bruce (Oxford University Press, 2009-5-21)
    Mild cognitive impairment can represent a transitional state between normal ageing and Alzheimer's disease. Non-invasive diagnostic methods are needed to identify mild cognitive impairment individuals for early therapeutic ...
  • MRI Parameters Of Alzheimer's Disease in an Arab Population of Wadi Ara, Israel 

    Bowirrat, Abdalla; Reider-Groswasser, Irith I; Oscar-Berman, Marlene; Aizenstein, Orna; Levy, Gad; Korczyn, Amos D (Dove Medical Press, 2005)
    Magnetic resonance imaging (MRI) findings are reported from 15 individuals in an Arab–Israeli community who were diagnosed with Alzheimer's disease (AD). The quantitative parameters that were used for MRI analyses included ...
  • Cognitive Aging in Zebrafish 

    Yu, Lili; Tucci, Valter; Kishi, Shuji; Zhdanova, Irina V. (Public Library of Science, 2006-12-20)
    BACKGROUND. Age-related impairments in cognitive functions represent a growing clinical and social issue. Genetic and behavioral characterization of animal models can provide critical information on the intrinsic and ...
  • Rule Knowledge Aids Performance on Spatial and Object Alternation Tasks by Alcoholic Patients with and Without Korsakoff's Amnesia 

    Bardenhagen, Fiona J.; Oscar-Berman, Marlene; Bowden, Stephen C. (Dove Medical Press, 2007)
    Delayed alternation (DA) and object alternation (OA) tasks traditionally have been used to measure defective response inhibition associated with dysfunction of frontal brain systems. However, these tasks are also sensitive ...
  • Activation instead of Blocking Mesolimbic Dopaminergic Reward Circuitry Is a Preferred Modality in the Long Term Treatment of Reward Deficiency Syndrome (RDS): A Commentary 

    Blum, Kenneth; Chen, Amanda Lih Chuan; Chen, Thomas J. H.; Braverman, Eric R.; Reinking, Jeffrey; Blum, Seth H.; Cassel, Kimberly; Downs, Bernard W.; Waite, Roger L.; Williams, Lonna; Prihoda, Thomas J.; Kerner, Mallory M.; Palomo, Tomas; Comings, David E.; Tung, Howard; Rhoades, Patrick; Oscar-Berman, Marlene (BioMed Central, 2008-11-12)
    BACKGROUND AND HYPOTHESIS. Based on neurochemical and genetic evidence, we suggest that both prevention and treatment of multiple addictions, such as dependence to alcohol, nicotine and glucose, should involve a biphasic ...
  • The Circadian System Is a Target and Modulator of Prenatal Cocaine Effects 

    Shang, Eva H.; Zhdanova, Irina V. (Public Library of Science, 2007-7-11)
    BACKGROUND. Prenatal exposure to cocaine can be deleterious to embryonic brain development, but the results in humans remain controversial, the mechanisms involved are not well understood and effective therapies are yet ...
  • Parallel Driving and Modulatory Pathways Link the Prefrontal Cortex and Thalamus 

    Zikopoulos, Basilis; Barbas, Helen (Public Library of Science, 2007-9-5)
    Pathways linking the thalamus and cortex mediate our daily shifts from states of attention to quiet rest, or sleep, yet little is known about their architecture in high-order neural systems associated with cognition, emotion ...
  • Distinct Parietal and Temporal Pathways to the Homologues of Broca's Area in the Monkey 

    Petrides, Michael; Pandya, Deepak N. (Public Library of Science, 2009-8-11)
    An unprecedented detailed analysis of ventrolateral frontal cortical circuitry in Broca's area of the non-human primate brain clarifies the functional pathways permitting interaction between posterior cortical areas and ...
  • Attention-Deficit-Hyperactivity Disorder and Reward Deficiency Syndrome 

    Blum, Kenneth; Chen, Amanda Lih-Chuan; Braverman, Eric R.; Comings, David E; Chen, Thomas J. H.; Arcuri, Vanessa; Blum, Seth H.; Downs, Bernard W.; Waite, Roger L.; Notaro, Alison; Lubar, Joel; Williams, Lonna; Prihoda, Thomas J.; Palomo, Tomas; Oscar-Berman, Marlene (Dove Medical Press, 2008)
    Molecular genetic studies have identified several genes that may mediate susceptibility to attention deficit hyperactivity disorder (ADHD). A consensus of the literature suggests that when there is a dysfunction in the ...
  • Diffuse Optical Signals in Response to Peripheral Nerve Stimulation Reflect Skeletal Muscle Kinematics 

    Erb, M. Kelley; Chen, Debbie K.; Sassaroli, Angelo; Fantini, Sergio; Bergethon, Peter R. (Optical Society of America, 2010-9-16)
    Previously we have reported a near-infrared optical response in the region occupied by a peripheral nerve that is distal to the site of electrical stimulation of that peripheral nerve. This "intermediate" signal is vascular ...
  • Cognitive-Behavior Therapy (CBT) for Panic Disorder: Relationship of Anxiety and Depression Comorbidity with Treatment Outcome 

    Allen, Laura B.; White, Kamila S.; Barlow, David H.; Shear, M. Katherine; Gorman, Jack M.; Woods, Scott W. (Springer US, 2009-7-24)
    Research evaluating the relationship of comorbidity to treatment outcome for panic disorder has produced mixed results. The current study examined the relationship of comorbid depression and anxiety to treatment outcome ...
  • Effects of tamoxifen on vaginal blood flow and epithelial morphology in the rat 

    Kim, Noel N.; Stankovic, Miljan; Armagan, Abdullah; Cushman, Tulay T.; Goldstein, Irwin; Traish, Abdulmaged M. (BioMed Central, 2006-9-13)
    BACKGROUND. Tamoxifen, a selective estrogen receptor modulator with both estrogenic and anti-estrogenic activity, is widely used as adjuvant therapy in breast cancer patients. Treatment with tamoxifen is associated with ...
  • Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers 

    Kim, Noel N.; Stankovic, Miljan; Cushman, Tulay T.; Goldstein, Irwin; Munarriz, Ricardo; Traish, Abdulmaged M. (BioMed Central, 2006-5-30)
    BACKGROUND. Diabetes is associated with declining sexual function in women. However, the effects of diabetes on genital tissue structure, innervation and function remains poorly characterized. In control and streptozotocin-treated ...
  • Frontal Brain Dysfunction in Alcoholism with and without Antisocial Personality Disorder 

    Oscar-Berman, Marlene; Valmas, Mary M.; Sawyer, Kayle S.; Kirkley, Shalene M.; Gansler, David A.; Merritt, Diane; Couture, Ashley (Dove Medical Press, 2009-06-10)
    Alcoholism and antisocial personality disorder (ASPD) often are comorbid conditions. Alcoholics, as well as nonalcoholic individuals with ASPD, exhibit behaviors associated with prefrontal brain dysfunction such as increased ...
  • Genetic Influences in Emotional Dysfunction and Alcoholism-Related Brain Damage 

    Oscar-Berman, Marlene; Bowirrat, Abdalla (Dove Medical Press, 2005)
    Alcoholism is a complex, multifactorial disorder involving problematic ethanol ingestion; it results from the interplay between genetic and environmental factors. Personality, likewise, is formed from a combination of ...
  • Test of Variables of Attention (TOVA) as a Predictor of Early Attention Complaints, an Antecedent to Dementia 

    Braverman, Eric R.; Chen, Amanda Lih-Chuan; Chen, Thomas J. H.; Schoolfield, John D; Notaro, Alison; Braverman, Dasha; Kerner, Mallory; Blum, Seth H.; Arcuri, Vanessa; Varshavskiy, Michael; Damle, Uma; Downs, B. William; Waite, Roger L.; Oscar-Berman, Marlene; Giordano, John; Blum, Kenneth (Dove Medical Press, 2010-10-15)
    The goal of this study was to determine if impairments detected by the test of variables of attention (TOVA) may be used to predict early attention complaints and memory impairments accurately in a clinical setting. We ...
  • Selective Disruption of the Cerebral Neocortex in Alzheimer's Disease 

    Desikan, Rahul S.; Sabuncu, Mert R.; Schmansky, Nicholas J.; Reuter, Martin; Cabral, Howard J.; Hess, Christopher P.; Weiner, Michael W.; Biffi, Alessandro; Anderson, Christopher D.; Rosand, Jonathan; Salat, David H.; Kemper, Thomas L.; Dale, Anders M.; Sperling, Reisa A.; Fischl, Bruce (Public Library of Science, 2010-9-23)
    BACKGROUND. Alzheimer's disease (AD) and its transitional state mild cognitive impairment (MCI) are characterized by amyloid plaque and tau neurofibrillary tangle (NFT) deposition within the cerebral neocortex and neuronal ...
  • Spectral and Spatial Dependence of Diffuse Optical Signals in Response to Peripheral Nerve Stimulation 

    Chen, Debbie K.; Erb, M. Kelley; Tong, Yunjie; Yu, Yang; Sassaroli, Angelo; Bergethon, Peter R.; Fantini, Sergio (Optical Society of America, 2010-9-16)
    Using non-invasive, near-infrared spectroscopy we have previously reported optical signals measured at or around peripheral nerves in response to their stimulation. Such optical signals featured amplitudes on the order of ...
  • Response Monitoring, Repetitive Behaviour and Anterior Cingulate Abnormalities in Autism Spectrum Disorders (ASD) 

    Thakkar, Katharine N.; Polli, Frida E.; Joseph, Robert M.; Tuch, David S.; Hadjikhani, Nouchine; Barton, Jason J. S.; Manoach, Dara S. (Oxford University Press, 2008-6-11)
    Autism spectrum disorders (ASD) are characterized by inflexible and repetitive behaviour. Response monitoring involves evaluating the consequences of behaviour and making adjustments to optimize outcomes. Deficiencies in ...

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