URI: http://hdl.handle.net/2144/2447

Recently Added

  • Oxysterol-Binding Protein-1 (OSBP1) Modulates Processing and Trafficking of the Amyloid Precursor Protein 

    Zerbinatti, Celina V.; Cordy, Joanna M.; Chen, Ci-Di; Guillily, Maria; Suon, Sokreine; Ray, William J.; Seabrook, Guy R.; Abraham, Carmela R.; Wolozin, Benjamin (BioMed Central, 2008-3-18)
    BACKGROUND Evidence from biochemical, epidemiological and genetic findings indicates that cholesterol levels are linked to amyloid-β (Aβ) production and Alzheimer's disease (AD). Oxysterols, which are cholesterol-derived ...
  • Distamycin A Inhibits HMGA1-Binding to the P-Selectin Promoter and Attenuates Lung and Liver Inflammation during Murine Endotoxemia 

    Baron, Rebecca M.; Lopez-Guzman, Silvia; Riascos, Dario F.; Macias, Alvaro A.; Layne, Matthew D.; Cheng, Guiying; Harris, Cailin; Chung, Su Wol; Reeves, Raymond; von Andrian, Ulrich H.; Perrella, Mark A. (Public Library of Science, 2010-5-14)
    BACKGROUND. The architectural transcription factor High Mobility Group-A1 (HMGA1) binds to the minor groove of AT-rich DNA and forms transcription factor complexes ("enhanceosomes") that upregulate expression of select ...
  • MURC/Cavin-4 and Cavin Family Members Form Tissue-Specific Caveolar Complexes 

    Bastiani, Michele; Liu, Libin; Hill, Michelle M.; Jedrychowski, Mark P.; Nixon, Susan J.; Lo, Harriet P.; Abankwa, Daniel; Luetterforst, Robert; Fernandez-Rojo, Manuel; Breen, Michael R.; Gygi, Steven P.; Vinten, Jorgen; Walser, Piers J.; North, Kathryn N.; Hancock, John F.; Pilch, Paul F.; Parton, Robert G. (The Rockefeller University Press, 2009-06-22)
    Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now ...
  • The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia 

    Grenz, Almut; Osswald, Hartmut; Eckle, Tobias; Yang, Dan; Zhang, Hua; Tran, Zung Vu; Klingel, Karin; Ravid, Katya; Eltzschig, Holger K. (Public Library of Science, 2008-6-24)
    BACKGROUND. Acute renal failure from ischemia significantly contributes to morbidity and mortality in clinical settings, and strategies to improve renal resistance to ischemia are urgently needed. Here, we identified ...
  • Tri-Nucleotide Receptors Play a Critical Role in Epithelial Cell Wound Repair 

    Weinger, Ilene; Klepeis, Veronica E.; Trinkaus-Randall, Vickery (Springer Netherlands, 2005-7-29)
    The cornea plays a major role in the refraction of light to the retina. Therefore, the integrity and transparency of the corneal epithelium are critical to vision. Following injury, a combination of rapid signal transduction ...
  • A Computational Approach for Deciphering the Organization of Glycosaminoglycans 

    Spencer, Jean L.; Bernanke, Joel A.; Buczek-Thomas, Jo Ann; Nugent, Matthew A. (Public Library of Science, 2010-2-23)
    BACKGROUND. Increasing evidence has revealed important roles for complex glycans as mediators of normal and pathological processes. Glycosaminoglycans are a class of glycans that bind and regulate the function of a wide ...
  • Cytokine Reduction in the Treatment of Joint Conditions 

    Sipe, J. D.; Martel-Pelletier, J.; Otterness, I. G.; Pelletier, J.-P. (Hindawi Publishing Corporation, 1994)
    The destruction of joints caused by rheumatoid arthritis and osteoarthritis is characterized by an imbalance of enzyme catalysed cartilage breakdown and regeneration. A complex cytokine network perpetuates joint conditions ...
  • A p130Cas Tyrosine Phosphorylated Substrate Domain Decoy Disrupts v-Crk Signaling 

    Kirsch, Kathrin H; Kensinger, Margaret; Hanafusa, Hidesaburo; August, Avery (BioMed Central, 2002-7-15)
    BACKGROUND. The adaptor protein p130Cas (Cas) has been shown to be involved in different cellular processes including cell adhesion, migration and transformation. This protein has a substrate domain with up to 15 tyrosines ...
  • Giardia Cyst Wall Protein 1 Is a Lectin That Binds to Curled Fibrils of the GalNAc Homopolymer 

    Chatterjee, Aparajita; Carpentieri, Andrea; Ratner, Daniel M.; Bullitt, Esther; Costello, Catherine E.; Robbins, Phillips W.; Samuelson, John (Public Library of Science, 2010-8-19)
    The infectious and diagnostic stage of Giardia lamblia (also known as G. intestinalis or G. duodenalis) is the cyst. The Giardia cyst wall contains fibrils of a unique β-1,3-linked N-acetylgalactosamine (GalNAc) homopolymer ...
  • Loss of AND-34/BCAR3 Expression in Mice Results in Rupture of the Adult Lens 

    Near, Richard I.; Smith, Richard S.; Toselli, Paul A.; Freddo, Thomas F.; Bloom, Alexander B.; Vanden Borre, Pierre; Seldin, David C.; Lerner, Adam (Molecular Vision, 2009-4-03)
    PURPOSE. AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor ...
  • Hematopoietic Gene Promoters Subjected to a Group-Combinatorial Study of DNA Samples: Identification of a Megakaryocytic Selective DNA Signature 

    Hazony, Yehonathan; Lu, Jun; St. Hilaire, Cynthia; Ravid, Katya (Oxford University Press, 2006-08-26)
    Identification of common sub-sequences for a group of functionally related DNA sequences can shed light on the role of such elements in cell-specific gene expression. In the megakaryocytic lineage, no one single unique ...
  • Mechanisms in Bradykinin Stimulated Arachidonate Release and Synthesis of Prostaglandin and Platelet Activating Factor 

    Ricupero, D.; Taylor, L.; Tlucko, A.; Navarro, J.; Polgar, P. (Hindawi Publishing Corporation, 1982)
    Regulatory mechanisms in bradykinin (BK) activated release of arachidonate (ARA) and synthesis of prostaglandin (PG) and platelet activating factor (PAF) were studied in bovine pulmonary artery endothelial cells (BPAEC). ...
  • Inhibition of Influenza M2-Induced Cell Death Alleviates Its Negative Contribution to Vaccination Efficiency 

    Ilyinskii, Petr O.; Gambaryan, Alexandra S.; Meriin, Anatoli B.; Gabai, Vladimir; Kartashov, Alex; Thoidis, Galini; Shneider, Alexander M. (Public Library of Science, 2008-1-16)
    The effectiveness of recombinant vaccines encoding full-length M2 protein of influenza virus or its ectodomain (M2e) have previously been tested in a number of models with varying degrees of success. Recently, we reported ...
  • Effects of tamoxifen on vaginal blood flow and epithelial morphology in the rat 

    Kim, Noel N.; Stankovic, Miljan; Armagan, Abdullah; Cushman, Tulay T.; Goldstein, Irwin; Traish, Abdulmaged M. (BioMed Central, 2006-9-13)
    BACKGROUND. Tamoxifen, a selective estrogen receptor modulator with both estrogenic and anti-estrogenic activity, is widely used as adjuvant therapy in breast cancer patients. Treatment with tamoxifen is associated with ...
  • Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers 

    Kim, Noel N.; Stankovic, Miljan; Cushman, Tulay T.; Goldstein, Irwin; Munarriz, Ricardo; Traish, Abdulmaged M. (BioMed Central, 2006-5-30)
    BACKGROUND. Diabetes is associated with declining sexual function in women. However, the effects of diabetes on genital tissue structure, innervation and function remains poorly characterized. In control and streptozotocin-treated ...
  • Immunodetection of nmt55/p54nrb isoforms in human breast cancer 

    Pavao, Matthew; Huang, Yue-Hua; Hafer, Laurie J.; Moreland, Robert B.; Traish, Abdulmaged M. (BioMed Central, 2001-10-29)
    BACKGROUND. We previously identified and characterized a novel 55 kDa nuclear protein, termed nmt55/p54nrb, whose expression was decreased in a subset of human breast tumors. The objective of this study was to determine ...
  • Tar DNA binding Protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue 

    Liu-Yesucevitz, Liqun; Bilgutay, Aylin; Zhang, Yong-Jie; Vanderwyde, Tara; Citro, Allison; Mehta, Tapan; Zaarur, Nava; McKee, Ann; Bowser, Robert; Sherman, Michael; Petrucelli, Leonard; Wolozin, Benjamin (Public Library of Science, 2010-10-11)
    Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). TDP-43 resides predominantly in the nucleus, ...
  • Temporal Profiling of the Secretome during Adipogenesis in Humans 

    Zhong, Jun; Krawczyk, Sarah A.; Chaerkady, Raghothama; Huang, Hailiang; Goel, Renu; Bader, Joel S.; Wong, G. William; Corkey, Barbara E.; Pandey, Akhilesh (American Chemical Society, 2010-08-14)
    Adipose tissue plays a key role as a fat-storage depot and as an endocrine organ. Although mouse adipogenesis has been studied extensively, limited studies have been conducted to characterize this process in humans. We ...
  • AMPK Exerts Dual Regulatory Effects on the PI3K Pathway 

    Tao, Rong; Gong, Jun; Luo, Xixi; Zang, Mengwei; Guo, Wen; Wen, Rong; Luo, Zhijun (BioMed Central, 2010-2-18)
    BACKGROUND AMP-activated protein kinase (AMPK) is a fuel-sensing enzyme that is activated when cells experience energy deficiency and conversely suppressed in surfeit of energy supply. AMPK activation improves insulin ...
  • Acyl Peptide Hydrolase Degrades Monomeric and Oligomeric Amyloid-Beta Peptide 

    Yamin, Rina; Zhao, Cheng; O'Connor, Peter B.; McKee, Ann C.; Abraham, Carmela R. (BioMed Central, 2009-7-23)
    BACKGROUND The abnormal accumulation of amyloid-beta peptide is believed to cause malfunctioning of neurons in the Alzheimer's disease brain. Amyloid-beta exists in different assembly forms in the aging mammalian brain ...

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