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  • Position of Eukaryotic Translation Initiation Factor eIF1A on the 40S Ribosomal Subunit Mapped by Directed Hydroxyl Radical Probing 

    Yu, Yingpu; Marintchev, Assen; Kolupaeva, Victoria G.; Unbehaun, Anett; Veryasova, Tatyana; Lai, Shao-Chiang; Hong, Peng; Wagner, Gerhard; Hellen, Christopher U. T.; Pestova, Tatyana V. (2009-8)
    The universally conserved eukaryotic initiation factor (eIF), eIF1A, plays multiple roles throughout initiation: it stimulates eIF2/GTP/Met-tRNAiMet attachment to 40S ribosomal subunits, scanning, start codon selection and ...
  • Crystal Structure of the P Pilus Rod Subunit PapA 

    Verger, Denis; Bullitt, Esther; Hultgren, Scott J; Waksman, Gabriel (Public Library of SciencePathogens, 2007-5-18)
    P pili are important adhesive fibres involved in kidney infection by uropathogenic Escherichia coli strains. P pili are assembled by the conserved chaperone-usher pathway, which involves the PapD chaperone and the PapC ...
  • High Density Lipoproteins-Based Therapies for Cardiovascular Disease 

    Gao, Xuan; Yuan, Shujun (Medknow Publications, 2010-07)
    Atherosclerosis is the leading cause of death in developed countries. High density lipoproteins (HDL) cholesterol level correlates inversely with the risk of cardiovascular diseases. Thus, HDL has obtained lots of interest ...
  • Molecular Model of the Microvillar Cytoskeleton and Organization of the Brush Border 

    Brown, Jeffrey W.; McKnight, C. James (Public Library of Science, 2010-2-24)
    BACKGROUND. Brush border microvilli are ~1-µm long finger-like projections emanating from the apical surfaces of certain, specialized absorptive epithelial cells. A highly symmetric hexagonal array of thousands of these ...
  • Metabolic Constraints on the Recovery of Sensitivity after Visual Pigment Bleaching in Retinal Rods 

    Miyagishima, Kiyoharu J.; Cornwall, M. Carter; Sampath, Alapakkam P. (The Rockefeller University Press, 2009-08-17)
    The shutoff of active intermediates in the phototransduction cascade and the reconstitution of the visual pigment play key roles in the recovery of sensitivity after the exposure to bright light in both rod and cone ...
  • The 9-Methyl Group of Retinal Is Essential for Rapid Meta II Decay and Phototransduction Quenching in Red Cones 

    Estevez, Maureen E.; Kolesnikov, Alexander V.; Ala-Laurila, Petri; Crouch, Rosalie K.; Govardovskii, Victor I.; Cornwall, M. Carter (The Rockefeller University Press, 2009-07-27)
    Cone photoreceptors of the vertebrate retina terminate their response to light much faster than rod photoreceptors. However, the molecular mechanisms underlying this rapid response termination in cones are poorly understood. ...
  • Capzb2 Interacts with β-Tubulin to Regulate Growth Cone Morphology and Neurite Outgrowth 

    Davis, David A.; Wilson, Meredith H.; Giraud, Jodel; Xie, Zhigang; Tseng, Huang-Chun; England, Cheryl; Herscovitz, Haya; Tsai, Li-Huei; Delalle, Ivana (Public Library of Science, 2009-10-6)
    An actin regulatory protein unexpectedly also controls microtubule polymerization during the formation and maintenance of cellular outgrowths in neurons. Capping protein (CP) is a heterodimer that regulates actin assembly ...
  • Evidence for a "Wattle and Daub" Model of the Cyst Wall of Entamoeba 

    Chatterjee, Anirban; Ghosh, Sudip K.; Jang, Ken; Bullitt, Esther; Moore, Landon; Robbins, Phillips W.; Samuelson, John (Public Library of Science, 2009-7-3)
    The cyst wall of Entamoeba invadens (Ei), a model for the human pathogen Entamoeba histolytica, is composed of fibrils of chitin and three chitin-binding lectins called Jacob, Jessie3, and chitinase. Here we show chitin, ...
  • Mechanisms in Bradykinin Stimulated Arachidonate Release and Synthesis of Prostaglandin and Platelet Activating Factor 

    Ricupero, D.; Taylor, L.; Tlucko, A.; Navarro, J.; Polgar, P. (Hindawi Publishing Corporation, 1982)
    Regulatory mechanisms in bradykinin (BK) activated release of arachidonate (ARA) and synthesis of prostaglandin (PG) and platelet activating factor (PAF) were studied in bovine pulmonary artery endothelial cells (BPAEC). ...
  • Structure of a Rabbit Muscle Fructose-1,6-Bisphosphate Aldolase A Dimer Variant 

    Sherawat, Manashi; Tolan, Dean R.; Allen, Karen N. (International Union of Crystallography, 2008-4-19)
    The X-ray crystallographic structure of a dimer variant of fructose-1,6-bisphosphate aldolase demonstrates a stable oligomer that mirrors half of the native tetramer. The presence of product demonstrates that this is an ...

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