Cardiovascular effects of electrolyte imbalance in the golden hamster

Abstract

Since high potassium levels are found in blood concurrently with vasoconstriction, it is important to establish the probable interrelationship. Consequently, cardiovascular effects of potassium and possible mechanisms of action were investigated using the cheek pouch of the golden hamster for direct observation of the microcirculation. The results presented in this dissertation were obtained from two related studies: first, by topical application of solutions containing altered concentrations of ions; and second, by intravenous injection of potassium salts. The vascular pattern of the cheek pouch was investigated and the relationship of structure to functional activity was established as a basis for analysis of comparative effects of solutions with varied salt concentrations. The structural components are arranged in a pattern typical of subcutaneous tissue. The smooth muscle components of the terminal vascular bed are capable of autonomous vasomotor activity, especially in the areas of the vascular sphincters. Vasomotor sensitivity was investigated by topical application of adrenaline chloride and by electrical stimulation of smooth muscle. [TRUNCATED]