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  • The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia 

    Grenz, Almut; Osswald, Hartmut; Eckle, Tobias; Yang, Dan; Zhang, Hua; Tran, Zung Vu; Klingel, Karin; Ravid, Katya; Eltzschig, Holger K. (Public Library of Science, 2008-6-24)
    BACKGROUND. Acute renal failure from ischemia significantly contributes to morbidity and mortality in clinical settings, and strategies to improve renal resistance to ischemia are urgently needed. Here, we identified ...
  • Redox-Sensitivity and Site-Specificity of S- and N- Denitrosation in Proteins 

    Jourd'heuil, Frances L.; Lowery, Anthony M.; Melton, Elaina M.; Mnaimneh, Sanie; Bryan, Nathan S.; Fernandez, Bernadette O.; Park, Joo-Ho; Ha, Chung-Eun; Bhagavan, Nadhipuram V.; Feelisch, Martin; Jourd'heuil, David (Public Library of Science, 2010-12-21)
    BACKGROUND. S-nitrosation - the formation of S-nitrosothiols (RSNOs) at cysteine residues in proteins - is a posttranslational modification involved in signal transduction and nitric oxide (NO) transport. Recent studies ...
  • ω-3 Polyunsaturated Fatty Acids Prevent Pressure Overload-Induced Ventricular Dilation and Decrease in Mitochondrial Enzymes Despite no Change in Adiponectin 

    O'Shea, Karen M; Chess, David J; Khairallah, Ramzi J; Hecker, Peter A; Lei, Biao; Walsh, Kenneth; Des Rosiers, Christine; Stanley, William C (BioMed Central, 2010-9-6)
    BACKGROUND Pathological left ventricular (LV) hypertrophy frequently progresses to dilated heart failure with suppressed mitochondrial oxidative capacity. Dietary marine ω-3 polyunsaturated fatty acids (ω-3 PUFA) up-regulate ...
  • Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice 

    Sanoudou, D.; Duka, A.; Drosatos, K.; Hayes, K. C.; Zannis, V. I. (Nature Publishing Group, 2009-12-01)
    We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment. Multilevel bioinformatical ...
  • Metabolic Profiling of the Human Response to a Glucose Challenge Reveals Distinct Axes of Insulin Sensitivity 

    Shaham, Oded; Wei, Ru; Wang, Thomas J.; Ricciardi, Catherine; Lewis, Gregory D.; Vasan, Ramachandran S.; Carr, Steven A.; Thadhani, Ravi; Gerszten, Robert E.; Mootha, Vamsi K. (Nature Publishing GroupMolecular Systems Biology, 2008-08-05)
    Glucose ingestion after an overnight fast triggers an insulin-dependent, homeostatic program that is altered in diabetes. The full spectrum of biochemical changes associated with this transition is currently unknown. We ...
  • Myogenic Akt Signaling Upregulates the Utrophin-Glycoprotein Complex and Promotes Sarcolemma Stability in Muscular Dystrophy 

    Peter, Angela K.; Ko, Christopher Y.; Kim, Michelle H.; Hsu, Nigel; Ouchi, Noriyuki; Rhie, Suhn; Izumiya, Yasuhiro; Zeng, Ling; Walsh, Kenneth; Crosbie, Rachelle H. (Oxford University Press, 2008-11-04)
    Duchenne muscular dystrophy is caused by dystrophin mutations that lead to structural instability of the sarcolemma membrane, myofiber degeneration/regeneration and progressive muscle wasting. Here we show that myogenic ...
  • Interpreting Metabolomic Profiles using Unbiased Pathway Models 

    Deo, Rahul C.; Hunter, Luke; Lewis, Gregory D.; Pare, Guillaume; Vasan, Ramachandran S.; Chasman, Daniel; Wang, Thomas J.; Gerszten, Robert E.; Roth, Frederick P. (Public Library of Science, 2010-2-26)
    Human disease is heterogeneous, with similar disease phenotypes resulting from distinct combinations of genetic and environmental factors. Small-molecule profiling can address disease heterogeneity by evaluating the ...
  • The Framingham Heart Study 100K SNP Genome-Wide Association Study Resource: Overview of 17 Phenotype Working Group Reports 

    Cupples, L. Adrienne; Arruda, Heather T.; Benjamin, Emelia J.; D'Agostino, Ralph B.; Demissie, Serkalem; DeStefano, Anita L.; Dupuis, Josée; Falls, Kathleen M.; Fox, Caroline S.; Gottlieb, Daniel J.; Govindaraju, Diddahally R.; Guo, Chao-Yu; Heard-Costa, Nancy L.; Hwang, Shih-Jen; Kathiresan, Sekar; Kiel, Douglas P.; Laramie, Jason M.; Larson, Martin G.; Levy, Daniel; Liu, Chun-Yu; Lunetta, Kathryn L.; Mailman, Matthew D.; Manning, Alisa K.; Meigs, James B.; Murabito, Joanne M.; Newton-Cheh, Christopher; O'Connor, George T.; O'Donnell, Christopher J.; Pandey, Mona; Seshadri, Sudha; Vasan, Ramachandran S.; Wang, Zhen Y.; Wilk, Jemma B.; Wolf, Philip A.; Yang, Qiong; Atwood, Larry D. (BioMed Central, 2007-9-19)
    BACKGROUND: The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the world. Many collected ...
  • Plasma Leptin Levels and Incidence of Heart Failure, Cardiovascular Disease, and Total Mortality in Elderly Individuals 

    Lieb, Wolfgang; Sullivan, Lisa M.; Harris, Tamara B.; Roubenoff, Ronenn; Benjamin, Emelia J.; Levy, Daniel; Fox, Caroline S.; Wang, Thomas J.; Wilson, Peter W.; Kannel, William B.; Vasan, Ramachandran S. (American Diabetes Association, 2008-12-29)
    OBJECTIVE: Obesity predisposes individuals to congestive heart failure (CHF) and cardiovascular disease (CVD). Leptin regulates energy homeostasis, is elevated in obesity, and influences ventricular and vascular remodeling. ...
  • Activation of Adenosine A2B Receptors Enhances Ciliary Beat Frequency in Mouse Lateral Ventricle Ependymal Cells 

    Genzen, Jonathan R; Yang, Dan; Ravid, Katya; Bordey, Angelique (BioMed Central, 2009-11-18)
    BACKGROUND: Ependymal cells form a protective monolayer between the brain parenchyma and cerebrospinal fluid (CSF). They possess motile cilia important for directing the flow of CSF through the ventricular system. While ...

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