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dc.contributor.authorLevy, Danielen_US
dc.contributor.authorDePalma, Steven R.en_US
dc.contributor.authorBenjamin, Emelia J.en_US
dc.contributor.authorO'Donnell, Christopher J.en_US
dc.contributor.authorParise, Helenen_US
dc.contributor.authorHirschhorn, Joel N.en_US
dc.contributor.authorVasan, Ramachandran S.en_US
dc.contributor.authorIzumo, Seigoen_US
dc.contributor.authorLarson, Martin G.en_US
dc.date.accessioned2011-12-29T20:57:39Z
dc.date.available2011-12-29T20:57:39Z
dc.date.copyright2006
dc.date.issued2006-5-22
dc.identifier.citationLevy, Daniel, Steven R. DePalma, Emelia J. Benjamin, Christopher J. O'Donnell, Helen Parise, Joel N. Hirschhorn, Ramachandran S. Vasan, Seigo Izumo, Martin G. Larson. "Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses." BMC Genetics 7:30. (2006)
dc.identifier.issn1471-2156
dc.identifier.urihttps://hdl.handle.net/2144/2482
dc.description.abstractBACKGROUND: High-throughput genotyping generates vast amounts of data for analysis; results can be difficult to summarize succinctly. A single project may involve genotyping many genes with multiple variants per gene and analyzing each variant in relation to numerous phenotypes, using several genetic models and population subgroups. Hundreds of statistical tests may be performed for a single SNP, thereby complicating interpretation of results and inhibiting identification of patterns of association. RESULTS: To facilitate visual display and summary of large numbers of association tests of genetic loci with multiple phenotypes, we developed a Phenotype-Genotype Association (PGA) grid display. A database-backed web server was used to create PGA grids from phenotypic and genotypic data (sample sizes, means and standard errors, P-value for association). HTML pages were generated using Tcl scripts on an AOLserver platform, using an Oracle database, and the ArsDigita Community System web toolkit. The grids are interactive and permit display of summary data for individual cells by a mouse click (i.e. least squares means for a given SNP and phenotype, specified genetic model and study sample). PGA grids can be used to visually summarize results of individual SNP associations, gene-environment associations, or haplotype associations. CONCLUSION: The PGA grid, which permits interactive exploration of large numbers of association test results, can serve as an easily adapted common and useful display format for large-scale genetic studies. Doing so would reduce the problem of publication bias, and would simplify the task of summarizing large-scale association studies.en_US
dc.description.sponsorshipNational Institutes of Health and National Heart, Lung, and Blood Institute (N01-HC-25195); National Institutes of Health Program for Genomic Applicationsen_US
dc.language.isoen
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2006 Levy et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.titlePhenotype-Genotype Association Grid: A Convenient Method for Summarizing Multiple Association Analysesen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1471-2156-7-30
dc.identifier.pmid16716207
dc.identifier.pmcid1526453


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Copyright 2006 Levy et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2006 Levy et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.