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dc.contributor.authorFox, Caroline S.en_US
dc.contributor.authorHeard-Costa, Nancyen_US
dc.contributor.authorCupples, L. Adrienneen_US
dc.contributor.authorDupuis, Joséeen_US
dc.contributor.authorVasan, Ramachandran S.en_US
dc.contributor.authorAtwood, Larry D.en_US
dc.date.accessioned2011-12-29T21:02:20Z
dc.date.available2011-12-29T21:02:20Z
dc.date.copyright2007
dc.date.issued2007-9-19
dc.identifier.citationFox, Caroline S, Nancy Heard-Costa, L Adrienne Cupples, Josée Dupuis, Ramachandran S Vasan, Larry D Atwood. "Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project" BMC Medical Genetics 8 (Suppl 1): S18. (2007)
dc.identifier.issn1471-2350
dc.identifier.urihttps://hdl.handle.net/2144/2511
dc.description.abstractBACKGROUND: Obesity is related to multiple cardiovascular disease (CVD) risk factors as well as CVD and has a strong familial component. We tested for association between SNPs on the Affymetrix 100K SNP GeneChip and measures of adiposity in the Framingham Heart Study. METHODS: A total of 1341 Framingham Heart Study participants in 310 families genotyped with the Affymetrix 100K SNP GeneChip had adiposity traits measured over 30 years of follow up. Body mass index (BMI), waist circumference (WC), weight change, height, and radiographic measures of adiposity (subcutaneous adipose tissue, visceral adipose tissue, waist circumference, sagittal height) were measured at multiple examination cycles. Multivariable-adjusted residuals, adjusting for age, age-squared, sex, smoking, and menopausal status, were evaluated in association with the genotype data using additive Generalized Estimating Equations (GEE) and Family Based Association Test (FBAT) models. We prioritized mean BMI over offspring examinations (1–7) and cohort examinations (10, 16, 18, 20, 22, 24, 26) and mean WC over offspring examinations (4–7) for presentation. We evaluated associations with 70,987 SNPs on autosomes with minor allele frequencies of at least 0.10, Hardy-Weinberg equilibrium p ≥ 0.001, and call rates of at least 80%. RESULTS: The top SNPs to be associated with mean BMI and mean WC by GEE were rs110683 (p-value 1.22*10-7) and rs4471028 (p-values 1.96*10-7). Please see for the complete set of results. We were able to validate SNPs in known genes that have been related to BMI or other adiposity traits, including the ESR1 Xba1 SNP, PPARG, and ADIPOQ. CONCLUSION: Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.en_US
dc.description.sponsorshipNational Heart, Lung, and Blood Institute's Framingham Heart Study (N01-HC-25195); Atwood (R01 DK066241); National Institutes of Health National Center for Research Resources Shared Instrumentation grant (1S10RR163736-01A1)en_US
dc.language.isoen
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2007 Fox et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.titleGenome-Wide Association to Body Mass Index and Waist Circumference: The Framingham Heart Study 100K Projecten_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1471-2350-8-S1-S18
dc.identifier.pmid17903300
dc.identifier.pmcid1995618


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Copyright 2007 Fox et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2007 Fox et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.