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dc.contributor.authorSárközi, Andreaen_US
dc.contributor.authorWyszynski, Diego Fen_US
dc.contributor.authorCzeizel, Andrew E.en_US
dc.date.accessioned2011-12-29T21:02:24Z
dc.date.available2011-12-29T21:02:24Z
dc.date.copyright2005
dc.date.issued2005-6-28
dc.identifier.citationSárközi, Andrea, Diego F Wyszynski, Andrew E Czeizel. "Oral clefts with associated anomalies: findings in the Hungarian Congenital Abnormality Registry" BMC Oral Health 5:4. (2005)
dc.identifier.issn1472-6831
dc.identifier.urihttps://hdl.handle.net/2144/2525
dc.description.abstractBACKGROUND: Over the years, great efforts have been made to record the frequency of orofacial clefts in different populations. However, very few studies were able to account for the etiological and phenotypic heterogeneity of these conditions. Thus, data of cases with syndromic orofacial clefts from large population-based studies are infrequent. METHODS: Clinically recognized and notified syndromes and associations including cleft lip with or without cleft palate and other congenital anomalies were selected from the Hungarian Congenital Abnormality Registry (HCAR) between 1973 and 1982 and prevalence rates were calculated. RESULTS: Of 3,110 cases reported as having orofacial clefts, 653 had multiple congenital abnormalities. Of these, 60 (9.2%) had a known etiology (monogenic: 25 or 3.8%, chromosomal: 31 or 4.7%, teratogenic: 4 or 0.6%). Seventy-three subjects (11.2%) had schisis in addition to the oral cleft. Skeletal anomalies were the most common malformations among cases with cleft lip with/without cleft palate (CL/P) and cleft palate (CP). Disorders of the central nervous system and cardiovascular malformations were also frequently associated. CONCLUSION: Surveillance systems, such as the HCAR, provide useful information about prevalence rates of congenital anomalies in a population. However, in a field where new syndromes are being discovered and classifications regularly updated, these rates should only be accepted as provisional.en_US
dc.description.sponsorshipMassachusetts Center for Birth Defects Research and Prevention of the Massachusetts Department of Public Health; Peer Foundation/Cleft Palate Foundation Etiology Granten_US
dc.language.isoen
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2005 Sárközi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.titleOral Clefts with Associated Anomalies: Findings in the Hungarian Congenital Abnormality Registryen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1472-6831-5-4
dc.identifier.pmid15985166
dc.identifier.pmcid1182377


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Copyright 2005 Sárközi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2005 Sárközi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.