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dc.contributor.authorMitri, Joannaen_US
dc.contributor.authorCastillo, Jorgeen_US
dc.contributor.authorPittas, Anastassios G.en_US
dc.date.accessioned2011-12-29T21:03:22Z
dc.date.available2011-12-29T21:03:22Z
dc.date.issued2011-12-29
dc.identifier.citationMitri, Joanna, Jorge Castillo, Anastassios G Pittas. "Diabetes and Risk of Non-Hodgkin's Lymphoma" Diabetes Care31(12): 2391-2397. (2008)en_US
dc.identifier.issn1935-5548en_US
dc.identifier.urihttps://hdl.handle.net/2144/2545
dc.description.abstractOBJECTIVE: To examine the epidemiologic association between diabetes and risk of non-Hodgkin's lymphoma (NHL). RESEARCH DESIGN AND METHODS: We searched MEDLINE for observational studies on the association between diabetes and NHL in adults using the keywords "diabetes" and "lymphoma." Prospective cohort studies that reported relative risks or standardized incidence ratios and case-control studies that reported odds ratios with 95% CIs were included. A random-effects model was used to combine results from the individual studies. RESULTS: A total of 15 manuscripts (reporting data from 5 prospective cohort and 11 case-control studies) met the inclusion criteria. Combining data from all studies, the risk ratio (RR) of developing NHL in patients with diabetes was 1.19 (95% CI 1.04–1.35). Based on prospective studies, patients with diabetes had an RR of developing NHL of 1.41 (1.07–1.88), without heterogeneity among studies (I2 = 34.3%; P > 0.10). Based on case-control studies, patients with diabetes had an RR of 1.12 (95% CI 0.95–1.31) of developing NHL compared with people without diabetes, with some heterogeneity among studies (I2 = 36.28%; P = 0.09). CONCLUSIONS: Diabetes is associated with a moderately increased risk of NHL, which is consistent with other reported associations between diabetes and malignancies. Future studies should focus on elucidating potential pathophysiologic links between diabetes and NHL.en_US
dc.description.sponsorshipNational Institutes of Health grants (R01-DK76092, R0179003, and R2178867)en_US
dc.language.isoenen_US
dc.publisherAmerican Diabetes Associationen_US
dc.rightsCopyright 2008, American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.en_US
dc.titleDiabetes and Risk of Non-Hodgkin's Lymphomaen_US
dc.typeArticleen_US
dc.identifier.doi10.2337/dc08-1034en_US
dc.identifier.pmid19033419en_US
dc.identifier.pmcid2584201en_US


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