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dc.contributor.authorSomkuwar, S. S.en_US
dc.contributor.authorKantak, K. M.en_US
dc.contributor.authorBardo, M. T.en_US
dc.contributor.authorDwoskin, L. P.en_US
dc.coverage.spatialUnited Statesen_US
dc.date2015-12-01
dc.date.accessioned2017-11-17T19:52:00Z
dc.date.available2017-11-17T19:52:00Z
dc.date.issued2016-02
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/26657171
dc.identifier.citationS. S. Somkuwar, K. M. Kantak, M. T. Bardo, L. P. Dwoskin. 2016. "Adolescent methylphenidate treatment differentially alters adult impulsivity and hyperactivity in the Spontaneously Hypertensive Rat model of ADHD.." Pharmacol Biochem Behav, v. 141, pp. 66 - 77.
dc.identifier.issn1873-5177
dc.identifier.urihttps://hdl.handle.net/2144/25613
dc.description.abstractImpulsivity and hyperactivity are two facets of attention deficit/hyperactivity disorder (ADHD). Impulsivity is expressed as reduced response inhibition capacity, an executive control mechanism that prevents premature execution of an intermittently reinforced behavior. During methylphenidate treatment, impulsivity and hyperactivity are decreased in adolescents with ADHD, but there is little information concerning levels of impulsivity and hyperactivity in adulthood after adolescent methylphenidate treatment is discontinued. The current study evaluated impulsivity, hyperactivity as well as cocaine sensitization during adulthood after adolescent methylphenidate treatment was discontinued in the Spontaneously Hypertensive Rat (SHR) model of ADHD. Treatments consisted of oral methylphenidate (1.5mg/kg) or water vehicle provided Monday-Friday from postnatal days 28-55. During adulthood, impulsivity was measured in SHR and control strains (Wistar Kyoto and Wistar rats) using differential reinforcement of low rate (DRL) schedules. Locomotor activity and cocaine sensitization were measured using the open-field assay. Adult SHR exhibited decreased efficiency of reinforcement under the DRL30 schedule and greater levels of locomotor activity and cocaine sensitization compared to control strains. Compared to vehicle, methylphenidate treatment during adolescence reduced hyperactivity in adult SHR, maintained the lower efficiency of reinforcement, and increased burst responding under DRL30. Cocaine sensitization was not altered following adolescent methylphenidate in adult SHR. In conclusion, adolescent treatment with methylphenidate followed by discontinuation in adulthood had a positive benefit by reducing hyperactivity in adult SHR rats; however, increased burst responding under DRL compared to SHR given vehicle, i.e., elevated impulsivity, constituted an adverse consequence associated with increased risk for cocaine abuse liability.en_US
dc.description.sponsorshipP50 DA005312 - NIDA NIH HHS; R01 DA011716 - NIDA NIH HHS; P50 DA05312 - NIDA NIH HHSen_US
dc.format.extentp. 66 - 77en_US
dc.languageeng
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.ispartofPharmacology Biochemistry Behavior
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNeurosciencesen_US
dc.subjectAttention deficit/hyperactivity disorderen_US
dc.subjectImpulsivityen_US
dc.subjectDifferential reinforcement of low rates scheduleen_US
dc.subjectMethylphenidateen_US
dc.subjectSpontaneously Hypertensive Raten_US
dc.subjectAgingen_US
dc.subjectAnimalsen_US
dc.subjectMaleen_US
dc.subjectRats, inbred SHRen_US
dc.subjectRats, inbred WKYen_US
dc.subjectRats, Wistaren_US
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectBehavioral sciencesen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectDopamine transporter functionen_US
dc.subjectMedial prefrontal cortexen_US
dc.subjectWistar-Kyoto Raten_US
dc.subjectDrug-naive boysen_US
dc.subjectResponse inhibitionen_US
dc.subjectAnimal modelen_US
dc.subjectNucleus accumbensen_US
dc.subjectSubstance abuseen_US
dc.subjectDisease models, animalen_US
dc.subjectCentral nervous system stimulantsen_US
dc.subjectAttention deficit disorder with hyperactivityen_US
dc.titleAdolescent methylphenidate treatment differentially alters adult impulsivity and hyperactivity in the Spontaneously Hypertensive Rat model of ADHDen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.pbb.2015.12.002
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Psychological & Brain Sciencesen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0003-1866-9485 (Kantak, KM)


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