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dc.contributor.authorNaveh, Gilien_US
dc.date.accessioned2018-01-23T20:11:25Z
dc.date.issued2017
dc.identifier.urihttps://hdl.handle.net/2144/26296
dc.description.abstractLigaments serve as compliant connectors between hard tissues. In that role, they function under various load regimes and directions. However, the 3D structure of ligaments is still considered uniform. The periodontal ligament connects the tooth to the bone and like other ligaments, it sustains different types of loads in various directions. Using the PDL as a model, and employing a fabricated motorized set-up in a microCT instrument, morphological automated segmentation methods and 2nd harmonic generation imaging, we demonstrate that the fibrous network structure within the PDL is not uniform, even before the tooth becomes functional. We find that areas sustaining compression loads are pre-structured with sparse collagenous networks and large blood vessels, whereas other areas contain dense collagen networks with few blood vessels. Therefore, the PDL develops as a non-uniform structure, with an architecture designed to sustain specific types of load in different areas. Based on these findings, we propose that ligaments in general should be regarded as non-uniform entities structured for optimal functioning under variable load regimes.en_US
dc.language.isoen_US
dc.subjectDentistryen_US
dc.titleNon uniformity: structural strategy for optimizing functionality in skeletal ligamentsen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2017-10-25T18:34:53Z
dc.description.embargo2019-09-26T00:00:00Z
etd.degree.nameMaster of Science in Designen_US
etd.degree.levelmastersen_US
etd.degree.disciplineOrthodontics and Dentofacial Orthopedicsen_US
etd.degree.grantorBoston Universityen_US


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