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    Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation

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    Date Issued
    2014-08-20
    Publisher Version
    10.1021/ja5060302
    Author(s)
    Grenning, Alexander J.
    Boyce, Jonathan H.
    Porco, John A.
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    Permanent Link
    https://hdl.handle.net/2144/26435
    Citation (published version)
    Alexander J Grenning, Jonathan H Boyce, John A Porco. 2014. "Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation.." J Am Chem Soc, Volume 136, Issue 33, pp. 11799 - 11804.
    Abstract
    Polyprenylated acylphloroglucinols (PPAPs) are structurally complex natural products with promising biological activities. Herein, we present a biosynthesis-inspired, diversity-oriented synthesis approach for rapid construction of PPAP analogs via double decarboxylative allylation (DcA) of acylphloroglucinol scaffolds to access allyl-desoxyhumulones followed by dearomative conjunctive allylic alkylation (DCAA).
    Rights
    © 2014 American Chemical Society. This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html), which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
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    • BU Open Access Articles [3664]
    • CAS: Chemistry: Scholarly Papers [120]


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