Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation
Grenning, Alexander J.
Boyce, Jonathan H.
Porco, John A.
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CitationAlexander J Grenning, Jonathan H Boyce, John A Porco. 2014. "Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation.." J Am Chem Soc, Volume 136, Issue 33, pp. 11799 - 11804.
Polyprenylated acylphloroglucinols (PPAPs) are structurally complex natural products with promising biological activities. Herein, we present a biosynthesis-inspired, diversity-oriented synthesis approach for rapid construction of PPAP analogs via double decarboxylative allylation (DcA) of acylphloroglucinol scaffolds to access allyl-desoxyhumulones followed by dearomative conjunctive allylic alkylation (DCAA).