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dc.contributor.authorHayashi, Mikayoen_US
dc.contributor.authorBrown, Lauren E.en_US
dc.contributor.authorPorco, John A.en_US
dc.coverage.spatialGermanyen_US
dc.date.accessioned2018-01-30T16:20:13Z
dc.date.available2018-01-30T16:20:13Z
dc.date.issued2016-10
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/28082832
dc.identifier.citationMikayo Hayashi, Lauren E Brown, John A Porco. 2016. "Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes.." European J Org Chem, Volume 2016, Issue 28, pp. 4800 - 4804.
dc.identifier.issn1434-193X
dc.identifier.urihttps://hdl.handle.net/2144/26486
dc.description.abstractEnantioenriched, polycyclic compounds were obtained from a simple acylphloroglucinol scaffold. Highly enantioselective dearomatization was accomplished using a Trost ligand-palladium(0) complex. A computational DFT model was developed to rationalize observed enantioselectivities and revealed a key reactant-ligand hydrogen bonding interaction. Dearomatized products were used in visible light-mediated photocycloadditions and oxidative free radical cyclizations to obtain novel polycyclic chemotypes including tricyclo[4.3.1.01,4]decan-10-ones, bicyclo[3.2.1]octan-8-ones and highly-substituted cycloheptanones.en_US
dc.description.sponsorshipR24 GM111625 - NIGMS NIH HHSen_US
dc.format.extent4800 - 4804en_US
dc.languageeng
dc.relation.ispartofEuropean J Org Chem
dc.subjectScience & technologyen_US
dc.subjectPhysical sciencesen_US
dc.subjectChemistry, organicen_US
dc.subjectChemistryen_US
dc.subjectAsymmetric catalysisen_US
dc.subjectDearomatizationen_US
dc.subjectPhotocatalysisen_US
dc.subjectRadical reactionsen_US
dc.subjectPolycyclesen_US
dc.subjectMedicinal and biomolecular chemistryen_US
dc.subjectOrganic chemistryen_US
dc.titleAsymmetric dearomatization/cyclization enables access to polycyclic chemotypesen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/ejoc.201601003
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Chemistryen_US
pubs.publication-statusPublisheden_US


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