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dc.contributor.authorWang, Wenyuen_US
dc.contributor.authorCencic, Reginaen_US
dc.contributor.authorWhitesell, Lukeen_US
dc.contributor.authorPelletier, Jerryen_US
dc.contributor.authorPorco, John A.en_US
dc.coverage.spatialGermanyen_US
dc.date.accessioned2018-01-30T16:23:59Z
dc.date.available2018-01-30T16:23:59Z
dc.date.issued2016-08-16
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/27338157
dc.identifier.citationWenyu Wang, Regina Cencic, Luke Whitesell, Jerry Pelletier, John A Porco. 2016. "Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition.." Chemistry, Volume 22, Issue 34, pp. 12006 - 12010.
dc.identifier.issn1521-3765
dc.identifier.urihttps://hdl.handle.net/2144/26487
dc.description.abstractSynthesis of aza-rocaglates, nitrogen-containing analogues of the rocaglate natural products, is reported. The route features ESIPT-mediated (3+2) photocycloaddition of 1-alkyl-2-aryl-3-hydroxyquinolinones with the dipolarophile methyl cinnamate. A continuous photoflow reactor was utilized for photocycloadditions. An array of compounds bearing the hexahydrocyclopenta[b]indole core structure was synthesized and evaluated in translation inhibition assays.en_US
dc.description.sponsorshipR01 CA175744 - NCI NIH HHS; R01 GM073855 - NIGMS NIH HHS; R24 GM111625 - NIGMS NIH HHS; R35 GM118173 - NIGMS NIH HHSen_US
dc.format.extent12006 - 12010en_US
dc.languageeng
dc.relation.ispartofChemistry
dc.subjectScience & technologyen_US
dc.subjectPhysical sciencesen_US
dc.subjectChemistryen_US
dc.subjectESIPTen_US
dc.subjectFlow chemistryen_US
dc.subjectHeterocyclesen_US
dc.subjectPhotocycloadditionen_US
dc.subjectRocaglateen_US
dc.subjectEukaryotic translationen_US
dc.subjectSilvestrol analogsen_US
dc.subjectFlavaglinesen_US
dc.subjectChemical sciencesen_US
dc.titleSynthesis of aza-rocaglates via ESIPT-mediated (3+2) photocycloadditionen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/chem.201602953
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Chemistryen_US
pubs.publication-statusPublisheden_US


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