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    D-cycloserine to enhance extinction of cue-elicited craving for alcohol: a translational approach.

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    This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated
otherwise in the credit line; if the material is not included under the Creative Commons
license, users will need to obtain permission from the license holder to reproduce the
material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
    Date Issued
    2015-04-07
    Publisher Version
    10.1038/tp.2015.41
    Author(s)
    MacKillop, J.
    Few, L. R.
    Stojek, M. K.
    Murphy, C. M.
    Malutinok, S. F.
    Johnson, F.T.
    Hofmann, S. G.
    McGeary, J. E.
    Swift, R. M.
    Monti, P. M.
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    Permanent Link
    https://hdl.handle.net/2144/26596
    Version
    Published version
    Citation (published version)
    J MacKillop, LR Few, MK Stojek, CM Murphy, SF Malutinok, FT Johnson, SG Hofmann, JE McGeary, RM Swift, PM Monti. 2015. "D-cycloserine to enhance extinction of cue-elicited craving for alcohol: a translational approach.." Transl Psychiatry, Volume 5, e544.
    Abstract
    Cue-elicited craving for alcohol is well established but extinction-based treatment to extinguish this response has generated only modest positive outcomes in clinical trials. Basic and clinical research suggests that D-cycloserine (DCS) enhances extinction to fear cues under certain conditions. However, it remains unclear whether DCS would also accelerate extinction of cue-elicited craving for alcohol. The goal of the current study was to examine whether, compared with placebo (PBO), DCS enhanced extinction of cue-elicited craving among treatment-seeking individuals with alcohol use disorders (AUDs). Participants were administered DCS (50 mg) or PBO 1 h before an alcohol extinction paradigm in a simulated bar environment on two occasions. The extinction procedures occurred 1 week apart and were fully integrated into outpatient treatment. Subjective craving for alcohol was the primary variable of interest. Follow-up cue reactivity sessions were conducted 1 week and 3 weeks later to ascertain persisting DCS effects. Drinking outcomes and tolerability were also examined. DCS was associated with augmented reductions in alcohol craving to alcohol cues during the first extinction session and these effects persisted through all subsequent sessions, suggesting facilitation of extinction. Participants in the DCS condition reported significant short-term reductions in drinking, although these did not persist to follow-up, and found the medication highly tolerable. These findings provide evidence that DCS enhances extinction of cue-elicited craving for alcohol in individuals with AUDs in the context of outpatient treatment. The potential clinical utility of DCS is discussed, including methodological considerations and context-dependent learning.
    Rights
    This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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    • BU Open Access Articles [3664]
    • CAS: Psychological and Brain Sciences: Scholarly Papers [232]


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