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dc.contributor.authorHofmann, Stefan G.en_US
dc.contributor.authorWu, Jade Q.en_US
dc.contributor.authorBoettcher, Hannahen_US
dc.coverage.spatialEnglanden_US
dc.date2013-05-17
dc.date.accessioned2018-02-01T18:23:27Z
dc.date.available2018-02-01T18:23:27Z
dc.date.issued2013-06-15
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/23768232
dc.identifier.citationStefan G Hofmann, Jade Q Wu, Hannah Boettcher. 2013. "D-Cycloserine as an augmentation strategy for cognitive behavioral therapy of anxiety disorders.." Biol Mood Anxiety Disord, Volume 3, Issue 1:11.
dc.identifier.issn2045-5380
dc.identifier.urihttps://hdl.handle.net/2144/26597
dc.description.abstractThe goal of this review is to examine the clinical studies on d-cycloserine, a partial glutamatergic N-methyl-D-aspartate agonist, as an augmentation strategy for exposure procedures during cognitive behavioral therapy for anxiety disorders. Although cognitive behavioral therapy and anxiolytic medications are more effective than placebo for treating anxiety disorders, there is still considerable room for further improvement. Traditional combination strategies typically yield disappointing results. However, recent studies based on translational research have shown promise to augment the neural circuitry underlying fear extinction with pharmacological means. We discuss the current state of the literature, including inconsistencies of findings and issues concerning the drug mechanism, dosing, and dose timing. D-cycloserine is a promising combination strategy for cognitive behavioral therapy of anxiety disorders by augmenting extinction learning. However, there is also evidence to suggest that d-cycloserine can facilitate reconsolidation of fear memory when exposure procedures are unsuccessful.en_US
dc.format.extent11 - ?en_US
dc.languageeng
dc.relation.ispartofBiol Mood Anxiety Disord
dc.rights© Hofmann et al. 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.subjectAnxiety disorderen_US
dc.subjectCognitive behavioral therapyen_US
dc.subjectGlutamateen_US
dc.subjectD-cycloserineen_US
dc.subjectPsychotherapyen_US
dc.subjectPharmacotherapyen_US
dc.titleD-Cycloserine as an augmentation strategy for cognitive behavioral therapy of anxiety disorders.en_US
dc.typeArticleen_US
dc.identifier.doi10.1186/2045-5380-3-11
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Psychological & Brain Sciencesen_US
pubs.publication-statusPublished onlineen_US
dc.identifier.orcid0000-0002-3548-9681 (Hofmann, Stefan G)


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© Hofmann et al. 2013.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as © Hofmann et al. 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.