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dc.contributor.authorGainey, Moniqueen_US
dc.date.accessioned2018-02-05T15:21:01Z
dc.date.available2018-02-05T15:21:01Z
dc.date.issued2017
dc.identifier.urihttps://hdl.handle.net/2144/26647
dc.description.abstractAs a common source of long-term pain and physical disability, overuse injuries, such as chronic tendinopathies, severely impact a patient’s quality of life. Caused by repetitive trauma, chronic tendinopathies affect hundreds of millions of people each year. The exact pathogenic mechanism in developing this musculoskeletal injury is still largely unknown, making clinical recommendations on the best course of treatment highly debatable. Nonetheless, advancements in biotechnology have made autologous blood products, specifically the use of platelet rich plasma injections, an increasingly popular method in the orthopedic field. Studies have shown that the concentrated platelet sample harbors a number of bioactive mediators. Once activated and injected at the site of injury, these growth factors and cytokines augment the natural healing process in tendinopathic cases. With limited reported complications, many clinicians believe that platelet rich plasma therapy is a safe and accessible treatment option for patients diagnosed with chronic tendinopathy. As such, the primary purpose of this paper is to determine the efficacy of platelet rich plasma injections in treating chronic tendinopathies. This literature review determined that current published studies and research on the effectiveness of PRP injections have produced contradictory results. Due to its autologous characteristic, platelet concentration differs significantly from patient to patient, contributing to high variability in terms of its effectiveness between patients. However, with low long-term costs and fast recovery, PRP injections are a promising, non-surgical intervention for treating chronic tendinopathies. Several patient-centered clinical studies have reported significant improvements in range of motion and pain management when compared to traditional injection treatments. These effects are maximized when administered under ultrasound guidance or when used in conjunction with a strict eccentric exercise program. Nonetheless, continued research is needed to determine optimal injection standards so that clinical recommendations can be further developed and supported.en_US
dc.language.isoen_US
dc.subjectMedicineen_US
dc.subjectChronic tendinopathyen_US
dc.subjectGrowth factorsen_US
dc.subjectOrthopedicsen_US
dc.subjectOveruse injuryen_US
dc.subjectPlatelet rich plasmaen_US
dc.subjectTreatmenten_US
dc.titleThe efficacy of using platelet rich plasma in treating chronic tendinopathiesen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2017-11-01T22:13:08Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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