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dc.contributor.authorAlousi, Faisal Fahden_US
dc.date.accessioned2018-02-05T15:31:06Z
dc.date.available2018-02-05T15:31:06Z
dc.date.issued2017
dc.identifier.urihttps://hdl.handle.net/2144/26653
dc.description.abstractThe increased risk of atherothrombosis in chronic kidney disease (CKD) has been under extensive examination for decades now. However, a treatment tailored for CKD patients is yet to be found. Current management plans can only tackle comorbidities and mostly fail. This thesis study examines the current literature related to CKD and thrombosis. The aim is to find a target suitable for therapeutic exploration. Normalizing the risk of thrombosis in CKD patients could curb a huge margin of their morbidity and mortality. In recent years, molecular biology studies attributed the extreme thrombogenicity in CKD to the retained uremic toxins. Indolic compounds are uremic toxins with a well described point of thrombotic activation. Of them, indoxyl sulfate is to be highlighted since it was shown to that it is one of the strongest pro-thrombotic uremic toxin. It is possible to therapeutically target this CKD specific cause of hyperthrombogenicity. Further research is very much needed in this area.en_US
dc.language.isoen_US
dc.subjectMedicineen_US
dc.subjectThrombosisen_US
dc.subjectChronic kidney diseaseen_US
dc.subjectIndoxyl sulfateen_US
dc.titleThe role of indoxyl sulfate in the increased incidence of thrombosis formation in chronic kidney diseaseen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2017-11-01T22:13:14Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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