Magnetization transfer effect on T1 relaxometry on 1.5T vs. 3T
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PURPOSE: To assess the variability of incidental magnetization transfer effect (MT) by the number of slices and the magnetic field strength. METHODS: Various magnetic resonance images (MRI) were obtained with a phantom containing a series of solutions of gadolinium (Gd) and sucrose in distilled water, agarose gel and two vials with olive oil and distilled water. A diffusion weighted image (DWI) sequence was acquired to determine diffusion coefficient for each component of the phantom. Several inversion recovery (IR) sequences having different TI values were run for single-slice and used to calculate T1 relaxation time with maximum precision and minimizing magnetization transfer effect. The T1 relaxation value resulting from processing IR sequences was used as reference value. The mixed-TSE sequences were used to calculate T1, T2 and PD values and to assess MT effect for single-slice as for multi-slice acquisition. All the DICOM MR images were processed using various algorithms programmed in Mathcad (version 2001i, PTC Needham, MA) by Dr. Hernan Jara. According with the potential of each sequences the programs generated the qMRI maps and values of T1, T2, PD were obtained for all the components of the phantom. Values resulted from Mathcad calculation were used for analysis. All the acquisitions, calculations and measurements were performed for 1.5T and 3T field strength.