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dc.contributor.authorZhang, Weixiaen_US
dc.contributor.authorLee, Sudaraten_US
dc.contributor.authorMcNear, Kelly L.en_US
dc.contributor.authorChung, Ting Fungen_US
dc.contributor.authorLee, Seunghyunen_US
dc.contributor.authorLee, Kyunghoonen_US
dc.contributor.authorCrist, Scott A.en_US
dc.contributor.authorRatliff, Timothy L.en_US
dc.contributor.authorZhong, Zhaohuien_US
dc.contributor.authorChen, Yong P.en_US
dc.contributor.authorYang, Chenen_US
dc.coverage.spatialEnglanden_US
dc.date2014-01-28
dc.date.accessioned2018-02-13T15:16:17Z
dc.date.available2018-02-13T15:16:17Z
dc.date.issued2014-02-14
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/24526127
dc.identifier.citationWeixia Zhang, Sudarat Lee, Kelly L McNear, Ting Fung Chung, Seunghyun Lee, Kyunghoon Lee, Scott A Crist, Timothy L Ratliff, Zhaohui Zhong, Yong P Chen, Chen Yang. 2014. "Use of graphene as protection film in biological environments.." Sci Rep, Volume 4:4097.
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/2144/27000
dc.description.abstractCorrosion of metal in biomedical devices could cause serious health problems to patients. Currently ceramics coating materials used in metal implants can reduce corrosion to some extent with limitations. Here we proposed graphene as a biocompatible protective film for metal potentially for biomedical application. We confirmed graphene effectively inhibits Cu surface from corrosion in different biological aqueous environments. Results from cell viability tests suggested that graphene greatly eliminates the toxicity of Cu by inhibiting corrosion and reducing the concentration of Cu(2+) ions produced. We demonstrated that additional thiol derivatives assembled on graphene coated Cu surface can prominently enhance durability of sole graphene protection limited by the defects in graphene film. We also demonstrated that graphene coating reduced the immune response to metal in a clinical setting for the first time through the lymphocyte transformation test. Finally, an animal experiment showed the effective protection of graphene to Cu under in vivo condition. Our results open up the potential for using graphene coating to protect metal surface in biomedical application.en_US
dc.format.extent4097en_US
dc.languageeng
dc.relation.ispartofSci Rep
dc.rightsThis work is licensed under a Creative Commons AttributionNonCommercial-NoDerivs 3.0 Unported license. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0
dc.subjectScience & technologyen_US
dc.subjectExpandable metal stentsen_US
dc.subjectOxidized zirconiumen_US
dc.subjectCopperen_US
dc.subjectArthroplastyen_US
dc.subjectGrapheneen_US
dc.subjectAnimalsen_US
dc.subjectCell proliferationen_US
dc.subjectCell survivalen_US
dc.subjectCells, cultureden_US
dc.subjectCoated materials, biocompatibleen_US
dc.subjectFemaleen_US
dc.subjectGraphiteen_US
dc.subjectHumansen_US
dc.subjectIonsen_US
dc.subjectLymphocytesen_US
dc.subjectMiceen_US
dc.subjectProstheses and implantsen_US
dc.subjectRatsen_US
dc.subjectRats, Long-Evansen_US
dc.subjectSulfhydryl compoundsen_US
dc.titleUse of graphene as protection film in biological environmentsen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/srep04097
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Electrical & Computer Engineeringen_US
pubs.publication-statusPublished onlineen_US
dc.identifier.orcid0000-0001-9454-847X (Yang, Chen)


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This work is licensed under a Creative Commons AttributionNonCommercial-NoDerivs 3.0 Unported license. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0.
Except where otherwise noted, this item's license is described as This work is licensed under a Creative Commons AttributionNonCommercial-NoDerivs 3.0 Unported license. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0.