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The BU-BMC Cancer Center’s mission is to provide high-quality patient care in combination with innovative research programs that will directly transform cancer management through the discovery of personalized approaches for cancer detection and treatment. Inherent in this vision is the focus on understanding the molecular events associated with cancer initiation and progression in high-risk populations, and the direct translation of these findings into the clinical realm. Find out more on the Cancer Center's website

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  • Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs 

    Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Kanara, Iphigenia; Mavrakis, Anastasios N.; Pernokas, Julie; Pernokas, Mark; Pinkert, Carl A.; Powers, Whitney R.; Sampani, Konstantina; Steliou, Kosta; Vavvas, Demetrios G.; Zamboni, Robert J.; Kodukula, Krishna; Chen, Xiaohong (Mary Ann Liebert, Inc., 2020)
    In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination ...
  • Epigenetic treatment of dermatologic disorders 

    Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Kanara, Iphigenia; Pinkert, Carl A.; Powers, Whitney R.; Sampani, Konstantina; Steliou, Kosta; Vavvas, Demetrios G.; Kodukula, Krishna; Zamboni, Robert J. (Wiley, 2019-09)
    Healthy skin protects us against a multitude of insults but injured or maladapted skin can lead to infection, inflammation or worse. Fortunately, naturally occurring bioactive products, many commonly found in olive oil and ...
  • Epigenetic treatment of persistent viral infections 

    Moos, Walter H.; Pinkert, Carl A.; Irwin, Michael H.; Faller, Douglas V.; Kodukula, Krishna; Glavas, Ioannis P.; Steliou, Kosta (Wiley, 2017-02-01)
    Approximately 2,500 years ago, Hippocrates used the word herpes as a medical term to describe lesions that appeared to creep or crawl on the skin, advocating heat as a possible treatment. During the last 50 years, ...
  • Epigenetic treatment of neuropsychiatric disorders: autism and schizophrenia 

    Moos, Walter H.; Maneta, Eleni; Pinkert, Carl A.; Irwin, Michael H.; Hoffman, Michelle E.; Faller, Douglas V.; Steliou, Kosta (John Wiley & Sons, Inc., 2016-03-01)
    Neuropsychiatric disorders are a heterogeneous group of conditions that often share underlying mitochondrial dysfunction and biological pathways implicated in their pathogenesis, progression, and treatment. To date, these ...
  • Epigenetic treatment of neurodegenerative disorders: Alzheimer and Parkinson diseases 

    Irwin, Michael H.; Moos, Walter H.; Faller, Douglas V.; Steliou, Kosta; Pinkert, Carl A. (Wiley-Blackwell, 2016-05-01)
    In this review we expand our discussion of epigenetic-driven methods for treating neurodegenerative disorders associated with mitochondrial dysfunction, focusing on carnitinoid antioxidant-histone deacetylase inhibitors ...
  • Antioxidant-mediated reversal of oxidative damage in mouse modeling of complex I inhibition 

    Parameshwaran, Kodeeswaran; Irwin, Michael H.; Steliou, Kosta; Suppiramaniam, Vishnu; Pinkert, Carl A. (Wiley-Blackwell, 2015-03-01)
    Mitochondrial dysfunction is a key component of various aging-related pathologies of the brain that result in dementia. As such, it provides an important avenue in development of therapeutic interventions for a host of ...
  • Bioprotective carnitinoids: lipoic acid, butyrate, and mitochondria-targeting to treat radiation injury: mitochondrial drugs come of age 

    Steliou, Kosta; Faller, Douglas V.; Pinkert, Carl A.; Irwin, Michael H.; Moos, Walter H. (Wiley-Blackwell, 2015-06-01)
    Given nuclear-power-plant incidents such as the 2011 Japanese Fukushima-Daiichi disaster, an urgent need for effective medicines to protect against and treat the harmful biological effects of radiation is evident. To address ...
  • Neuroprotective effects of carnitinoid compounds in rodent cellular and in vivo models of mitochondrial complex I dysfunction 

    Steliou, Kosta (Mesford Publisher Inc, 2019-03-13)
    Rotenone-mediated mitochondrial complex I inhibition was used to model Parkinson’s disease-like syndrome in Lewis rats. Tyrosine hydroxylase immunolabeling demonstrated a decrease in the number of dopaminergic neurons as ...
  • Epigenetic treatment of neurodegenerative ophthalmic disorders: an eye toward the future. 

    Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Irwin, Michael H.; Kanara, Iphigenia; Pinkert, Carl A.; Powers, Whitney R.; Steliou, Kosta; Vavvas, Demetrios G.; Kodukula, Krishna (2017)
    Eye disease is one of the primary medical conditions that requires attention and therapeutic intervention in ageing populations worldwide. Further, the global burden of diabetes and obesity, along with heart disease, all ...
  • Telomeric DNA Induces Apoptosis and Senescence of Human Breast Carcinoma Cells 

    Yaar, Mina; Eller, Mark S.; Panova, Izabela; Kubera, John; Wee, Lee Hng; Cowan, Kenneth H.; Gilchrest, Barbara A. (BioMed Central, 2007-1-26)
    INTRODUCTION. Cancer is a leading cause of death in Americans. We have identified an inducible cancer avoidance mechanism in cells that reduces mutation rate, reduces and delays carcinogenesis after carcinogen exposure, ...

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