Sensorimotor adaptation of voice fundamental frequency in Parkinson's disease

Date Issued
2018Publisher Version
10.1371/journal.pone.0191839Author(s)
Abur, Defne
Lester-Smith, Rosemary A.
Daliri, Ayoub
Lupiani, Ashling A
Guenther, Frank H
Stepp, Cara E
Metadata
Show full item recordPermanent Link
https://hdl.handle.net/2144/27108Citation (published version)
Defne Abur, Rosemary A Lester-Smith, Ayoub Daliri, Ashling A Lupiani, Frank H Guenther, Cara E Stepp. 2018. "Sensorimotor adaptation of voice fundamental frequency in Parkinson's disease.." PLoS One, Volume 13, Issue 1:e0191839.Abstract
OBJECTIVE: This study examined adaptive responses to auditory perturbation of fundamental frequency (fo) in speakers with Parkinson's disease (PD) and control speakers. METHOD: Sixteen speakers with PD and nineteen control speakers produced sustained vowels while they received perturbed auditory feedback (i.e., fo shifted upward or downward). Speakers' pitch acuity was quantified using a just-noticeable-difference (JND) paradigm. Twelve listeners provided estimates of the speech intelligibility for speakers with PD. RESULTS: Fifteen responses from each speaker group for each shift direction were included in analyses. While control speakers generally showed consistent adaptive responses opposing the perturbation, speakers with PD showed no compensation on average, with individual PD speakers showing highly variable responses. In the PD group, the degree of compensation was not significantly correlated with age, disease progression, pitch acuity, or intelligibility. CONCLUSIONS: These findings indicate reduced adaptation to sustained fo perturbation and higher variability in PD compared to control participants. No significant differences were seen in pitch acuity between groups, suggesting that the fo adaptation deficit in PD is not the result of purely perceptual mechanisms. SIGNIFICANCE: These results suggest there is an impairment in vocal motor control in PD. Building on these results, contributions can be made to developing targeted voice treatments for PD. OBJECTIVE
This study examined adaptive responses to auditory perturbation of fundamental frequency (fo) in speakers with Parkinson’s disease (PD) and control speakers.
METHOD
Sixteen speakers with PD and nineteen control speakers produced sustained vowels while they received perturbed auditory feedback (i.e., fo shifted upward or downward). Speakers’ pitch acuity was quantified using a just-noticeable-difference (JND) paradigm. Twelve listeners provided estimates of the speech intelligibility for speakers with PD.
RESULTS
Fifteen responses from each speaker group for each shift direction were included in analyses. While control speakers generally showed consistent adaptive responses opposing the perturbation, speakers with PD showed no compensation on average, with individual PD speakers showing highly variable responses. In the PD group, the degree of compensation was not significantly correlated with age, disease progression, pitch acuity, or intelligibility.
CONCLUSIONS
These findings indicate reduced adaptation to sustained fo perturbation and higher variability in PD compared to control participants. No significant differences were seen in pitch acuity between groups, suggesting that the fo adaptation deficit in PD is not the result of purely perceptual mechanisms.
SIGNIFICANCE
These results suggest there is an impairment in vocal motor control in PD. Building on these results, contributions can be made to developing targeted voice treatments for PD.
Rights
Copyright: © 2018 Abur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Collections