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  • CD1c Bypasses Lysosomes to Present a Lipopeptide Antigen with 12 Amino Acids 

    Van Rhijn, Ildiko; Young, David C.; De Jong, Annemieke; Vazquez, Jenny; Cheng, Tan-Yun; Talekar, Rahul; Barral, Duarte C.; León, Luis; Brenner, Michael B.; Katz, Joel T.; Riese, Richard; Ruprecht, Ruth M.; O'Connor, Peter B.; Costello, Catherine E.; Porcelli, Steven A.; Briken, Volker; Moody, D. Branch (The Rockefeller University Press, 2009-05-25)
    The recent discovery of dideoxymycobactin (DDM) as a ligand for CD1a demonstrates how a nonribosomal lipopeptide antigen is presented to T cells. DDM contains an unusual acylation motif and a peptide sequence present only ...
  • Acyl Peptide Hydrolase Degrades Monomeric and Oligomeric Amyloid-Beta Peptide 

    Yamin, Rina; Zhao, Cheng; O'Connor, Peter B.; McKee, Ann C.; Abraham, Carmela R. (BioMed Central, 2009-7-23)
    BACKGROUND The abnormal accumulation of amyloid-beta peptide is believed to cause malfunctioning of neurons in the Alzheimer's disease brain. Amyloid-beta exists in different assembly forms in the aging mammalian brain ...