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dc.contributor.authorMegirian, Roberten_US
dc.date.accessioned2018-02-26T19:30:40Z
dc.date.available2018-02-26T19:30:40Z
dc.date.issued1957
dc.date.submitted1957
dc.identifier.otherb14660386
dc.identifier.urihttps://hdl.handle.net/2144/27252
dc.descriptionThesis (Ph.D.)--Boston Universityen_US
dc.description.abstractIn this study, propallorphan (a-3-hydroxy-N-propargylmorphina.n, Ro-1-7780) was found to be a potent alphaprodine to alphaprodine in both dog and man. The depression of general responsiveness (objective signs of central nervous system stimulation or depression) in conscious dogs by morphine and alphaprodine was reversed by propallorphan; while in anesthetized dogs, the changes in blood and expired gases as well as respiration brought about by alphaprodine were also antagonized by propallorphan. In another series of experiments, ratios of propallorphan to alphaprodine of 1:75 or 1:100 prevented the respiratory depression normally produced by the narcotic alone. It was also found that this antagonist reversed the respiratory depression produced by morphine; the effect lasted for a period of 30 minutes only before the opiate induced depression was reinstated. [TRUNCATED]en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.rightsBased on investigation of the BU Libraries' staff, this work is free of known copyright restrictions.en_US
dc.titleThe antagonism of narcotics by L-3-Hydroxy-N-Allylmorphinan (Levallorphan) L-3-Hydroxy-N-Propargylmorphinan (Propallorophan) and 2,4-Diamino-5-Phenylthiazole (Daptazole)en_US
dc.typeThesis/Dissertationen_US
etd.degree.nameDoctor of Philosophyen_US
etd.degree.leveldoctoralen_US
etd.degree.disciplinePhilosophyen_US
etd.degree.grantorBoston Universityen_US


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