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  • Marburg Virus Evades Interferon Responses by a Mechanism Distinct from Ebola Virus 

    Valmas, Charalampos; Grosch, Melanie N.; Schümann, Michael; Olejnik, Judith; Martinez, Osvaldo; Best, Sonja M.; Krähling, Verena; Basler, Christopher F.; Mühlberger, Elke (Public Library of Science, 2010-1-15)
    Previous studies have demonstrated that Marburg viruses (MARV) and Ebola viruses (EBOV) inhibit interferon (IFN)-α/β signaling but utilize different mechanisms. EBOV inhibits IFN signaling via its VP24 protein which blocks ...
  • TB Database: An Integrated Platform for Tuberculosis Research 

    Reddy, T. B. K.; Riley, Robert; Wymore, Farrell; Montgomery, Phillip; DeCaprio, Dave; Engels, Reinhard; Gellesch, Marcel; Hubble, Jeremy; Jen, Dennis; Jin, Heng; Koehrsen, Michael; Larson, Lisa; Mao, Maria; Nitzberg, Michael; Sisk, Peter; Stolte, Christian; Weiner, Brian; White, Jared; Zachariah, Zachariah K.; Sherlock, Gavin; Galagan, James E.; Ball, Catherine A.; Schoolnik, Gary K. (Nucleic Acids Research, 2009-1)
    The effective control of tuberculosis (TB) has been thwarted by the need for prolonged, complex and potentially toxic drug regimens, by reliance on an inefficient vaccine and by the absence of biomarkers of clinical status. ...
  • Vesicular Stomatitis Virus-Based Ebola Vaccine Is Well-Tolerated and Protects Immunocompromised Nonhuman Primates 

    Geisbert, Thomas W.; Daddario-DiCaprio, Kathleen M.; Lewis, Mark G.; Geisbert, Joan B.; Grolla, Allen; Leung, Anders; Paragas, Jason; Matthias, Lennox; Smith, Mark A.; Jones, Steven M.; Hensley, Lisa E.; Feldmann, Heinz; Jahrling, Peter B. (Public Library of Science Pathogens, 2008-11-28)
    Ebola virus (EBOV) is a significant human pathogen that presents a public health concern as an emerging/re-emerging virus and as a potential biological weapon. Substantial progress has been made over the last decade in ...
  • Development of an Acute and Highly Pathogenic Nonhuman Primate Model of Nipah Virus Infection 

    Geisbert, Thomas W.; Daddario-DiCaprio, Kathleen M.; Hickey, Andrew C.; Smith, Mark A.; Chan, Yee-Peng; Wang, Lin-Fa; Mattapallil, Joseph J.; Geisbert, Joan B.; Bossart, Katharine N.; Broder, Christopher C. (Public Library of Science, 2010-5-18)
    Nipah virus (NiV) is an enigmatic emerging pathogen that causes severe and often fatal neurologic and/or respiratory disease in both animals and humans. Amongst people, case fatality rates range between 40 and 75 percent ...