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dc.contributor.authorMcCracken, Johnen_US
dc.contributor.authorBaccarelli, Andreaen_US
dc.contributor.authorHoxha, Mirjamen_US
dc.contributor.authorDioni, Lauraen_US
dc.contributor.authorMelly, Steveen_US
dc.contributor.authorCoull, Brenten_US
dc.contributor.authorSuh, Helenen_US
dc.contributor.authorVokonas, Pantelen_US
dc.contributor.authorSchwartz, Joelen_US
dc.date.accessioned2012-01-09T14:20:00Z
dc.date.available2012-01-09T14:20:00Z
dc.date.issued2010-11en_US
dc.identifier.citationMcCracken, John, Andrea Baccarelli, Mirjam Hoxha, Laura Dioni, Steve Melly, Brent Coull, Helen Suh, Pantel Vokonas, Joel Schwartz. "Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study" Environmental Health Perspectives 118(11): 1564-1570. (2010)en_US
dc.identifier.issn1552-9924en_US
dc.identifier.urihttps://hdl.handle.net/2144/2751
dc.description.abstractBACKGROUND. Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. OBJECTIVE. We investigated whether ambient black carbon (BC), a marker for traffic-related particles, is associated with telomere length in the Normative Aging Study (NAS). METHODS. Among 165 never-smoking men from the NAS, leukocyte telomere length (LTL) was measured repeatedly approximately every 3 years from 1999 through 2006 using quantitative real-time polymerase chain reaction (qRT-PCR). BC concentration at their residences during the year before each LTL measurement was estimated based on a spatiotemporal model calibrated with BC measurements from 82 locations within the study area. RESULTS. The median [interquartile range (IQR)] annual moving-average BC concentration was 0.32 (0.20-0.45) μg/m^3. LTL, expressed as population-standardized ratio of telomere repeat to single-copy gene copy numbers, had a geometric mean (geometric SD) of 1.25 (1.42). We used linear mixed-effects models including random subject intercepts and adjusted for several potential confounders. We used inverse probability of response weighting to adjust for potential selection bias due to loss to follow-up. An IQR increase in annual BC (0.25 μg/m3) was associated with a 7.6% decrease (95% confidence interval, -12.8 to -2.1) in LTL. We found evidence of effect modification, with a stronger association among subjects ≥ 75 years of age compared with younger participants (p = 0.050) and statin medications appearing protective of the effects of BC on LTL (p = 0.050). CONCLUSIONS. Telomere attrition, linked to biological aging, may be associated with long-term exposures to airborne particles, particularly those rich in BC, which are primarily related to automobile traffic.en_US
dc.description.sponsorshipUnited States Department of Veterans Affairs; Massachusetts Veterans Epidemiological Research and Information Center; United States Environmental Protection Agency (R827353, R832416); National Institutes of Health (R01-ES015172, ES014663, ES-0002, ES009825)en_US
dc.language.isoenen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.rightsThis is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.en_US
dc.subjectAir pollutionen_US
dc.subjectBiological agingen_US
dc.subjectCardiovascular physiologyen_US
dc.subjectEnvironmental exposureen_US
dc.subjectEpigenetic processen_US
dc.subjectParticlesen_US
dc.subjectTrafficen_US
dc.subjectVehicle emissionsen_US
dc.titleAnnual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1289/ehp.0901831en_US
dc.identifier.pmcid2974694en_US


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