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dc.contributor.authorWilker, Elissa H.en_US
dc.contributor.authorBaccarelli, Andreaen_US
dc.contributor.authorSuh, Helenen_US
dc.contributor.authorVokonas, Pantelen_US
dc.contributor.authorWright, Robert O.en_US
dc.contributor.authorSchwartz, Joelen_US
dc.date.accessioned2012-01-09T14:20:01Z
dc.date.available2012-01-09T14:20:01Z
dc.date.issued2010-07
dc.identifier.citationWilker, Elissa H., Andrea Baccarelli, Helen Suh, Pantel Vokonas, Robert O. Wright, Joel Schwartz. "Black Carbon Exposures, Blood Pressure, and Interactions with Single Nucleotide Polymorphisms in MicroRNA Processing Genes" Environmental Health Perspectives 118(7): 943-948. (2010)
dc.identifier.issn1552-9924
dc.identifier.urihttps://hdl.handle.net/2144/2755
dc.description.abstractBACKGROUND. Black carbon (BC) is a marker of traffic pollution that has been associated with blood pressure (BP), but findings have been inconsistent. MicroRNAs (miRNAs) are emerging as key regulators of gene expression, but whether polymorphisms in genes involved in processing of miRNAs to maturity influence susceptibility to BC has not been elucidated. OBJECTIVES. We investigated the association between BC and BP, as well as potential effect modification by single nucleotide polymorphisms (SNPs) in miRNA processing genes. METHODS. Repeated measures analyses were performed using data from the VA Normative Aging Study. Complete covariate data were available for 789 participants with one to six study visits between 1995 and 2008. In models of systolic and diastolic BP, we examined SNP-by-BC interactions with 19 miRNA-related variants under recessive models of inheritance. Mixed-effects models were adjusted for potential confounders including clinical characteristics, lifestyle, and meteorologic factors. RESULTS. A 1-SD increase in BC (0.415 μg/m3) was associated with 3.04 mmHg higher systolic (95% confidence interval (CI), 2.29–3.79) and 2.28 mmHg higher diastolic BP (95% CI, 1.88–2.67). Interactions modifying BC associations were observed with SNPs in the DICER, GEMIN4, and DiGeorge critical region-8 (DGCR8) genes, and in GEMIN3 and GEMIN4, predicting diastolic and systolic BP, respectively. CONCLUSIONS. We observed evidence of effect modification of the association between BP and 7-day BC moving averages by SNPs associated with miRNA processing. Although the mechanisms underlying these associations are not well understood, they suggest a role for miRNA genesis and processing in influencing BC effects.en_US
dc.description.sponsorshipNational Institute of Environmental Health Sciences (ES 14663, ES 15172, ES 00002, P01 ES09825); United States Environmental Protection Agency (R832416, T32-07069, T32-HL007374-30); Massachusetts Veterans Epidemiology Research and Information Center; United States Department of Veterans Affairsen_US
dc.language.isoen
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.rightsThis is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.en_US
dc.subjectBlack carbonen_US
dc.subjectBlood pressureen_US
dc.subjectEpigenetic mechanismsen_US
dc.subjectGene-environment interactionsen_US
dc.subjectGenetic polymorphismsen_US
dc.titleBlack Carbon Exposures, Blood Pressure, and Interactions with Single Nucleotide Polymorphisms in MicroRNA Processing Genesen_US
dc.typeArticleen_US
dc.identifier.doi10.1289/ehp.0901440
dc.identifier.pmid20211803
dc.identifier.pmcid2920913


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