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dc.contributor.authorDevine, Sheryl A.en_US
dc.contributor.authorKirkley, Shalene M.en_US
dc.contributor.authorPalumbo, Carole L.en_US
dc.contributor.authorWhite, Roberta F.en_US
dc.date.accessioned2012-01-09T14:33:25Z
dc.date.available2012-01-09T14:33:25Z
dc.date.issued2002-10
dc.identifier.citationDevine, Sherral A, Shalene M Kirkley, Carole L Palumbo, Roberta F White. "MRI and Neuropsychological Correlates of Carbon Monoxide Exposure: A Case Report." Environmental Health Perspectives 110(10): 1051-1055. (2002)
dc.identifier.urihttps://hdl.handle.net/2144/2762
dc.description.abstractA 45-year-old woman experienced long-term, chronic exposure to carbon monoxide in the restaurant kitchen where she was employed as a cook. After returning to the restaurant after 5 days off work, she noticed that her symptoms returned immediately; she then aired out the room and called the gas company. Approximately 6 hr after a leak was detected, the patient went to the hospital, where her carboxyhemoglobin was found to be within normal limits and results of a neurologic examination were described as normal. Based on her symptoms, the patient believed she had been exposed to CO for at least 1 year before the leak was discovered. Initially, she experienced flu-like symptoms, which eventually resolved. At the time of her first neuropsychological evaluation (17 months after the exposure was identified), her persisting complaints included difficulties in reading, writing, speaking and word retrieval. The test results were consistent with secondary frontal lobe dysfunction associated with subcortical disorders such as those seen after CO exposure. Results of a subsequent neuropsychological examination (29 months postexposure) showed slight improvement in performance, but her performance was still consistent with mild frontal/subcortical dysfunction. Although the initial screening of a brain magnetic resonance image (MRI) performed 15 months after the exposure was interpreted as being within normal limits, two subsequent blind reviews of the same scans identified multiple bilateral lesions in the basal ganglia, which were consistent with chronic CO exposure. We present this case as an example of the utility of MRI and neuropsychological examinations in detecting central nervous system dysfunction secondary to CO exposure.en_US
dc.language.isoen
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.subjectCarbon monoxideen_US
dc.subjectNeuropsychologyen_US
dc.subjectToxicant-induced encephalopathyen_US
dc.subjectNeuroimagingen_US
dc.subjectMRIen_US
dc.subjectNeurobehavioral methodsen_US
dc.titleMRI and Neuropsychological Correlates of Carbon Monoxide Exposure: A Case Reporten_US
dc.typeArticleen_US
dc.identifier.pmid12361932
dc.identifier.pmcid1241033


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