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dc.contributor.authorPaulu, Christopheren_US
dc.contributor.authorAschengrau, Annen_US
dc.contributor.authorOzonoff, Daviden_US
dc.date.accessioned2012-01-09T14:33:26Z
dc.date.available2012-01-09T14:33:26Z
dc.date.issued2002-05en_US
dc.identifier.citationPaulu, Christopher, Ann Aschengrau, David Ozonoff. "Exploring Associations Between Residential Location and Breast Cancer Incidence in a Case-Control Study." Environmental Health Perspectives 110(5): 471-478. (2002)en_US
dc.identifier.urihttps://hdl.handle.net/2144/2763
dc.description.abstractLocating geographic hot spots of cancer may lead to new causal hypotheses and ultimately to new knowledge of cancer-causing factors. The Cape Cod region of Massachusetts has experienced elevated incidence of breast cancer compared with statewide averages. The origins of the excess remain largely unexplained, even after the Upper Cape Cod Cancer Incidence Study investigated numerous potential environmental exposures. Using case-control data from this study (258 cases and 686 controls), we developed an exploratory approach for measuring associations between residential location and breast cancer incidence, adjusting for individual-level risk factors. We measured crude and adjusted odds ratios over the study region using fixed-scale grids and a smoothing algorithm of overlapping circular units. Polycircular hot spot regions, derived from the peak values of the smoothed odds ratios, delineated geographic areas wherein residence was associated with 60% [odds ratio (OR), 1.6; 95% confidence interval (CI), 0.8-3.2] to 210% (OR, 3.1; 95% CI, 1.3-7.2) increased incidence relative to the remainder of the study population. The findings suggest several directions for further research, including the identification of potential environmental exposures that may be assessed in forthcoming case-control studies.en_US
dc.description.sponsorshipNational Institute of Environmental Health Sciences (2P42 ES07381); National Institutes of Health; United States Environmental Protection Agency; Silent Spring Institute; Massachusetts Deparment of Public Healthen_US
dc.language.isoenen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.subjectBreast canceren_US
dc.subjectCase-control studiesen_US
dc.subjectCluster analysisen_US
dc.subjectEpidemiologic methodsen_US
dc.subjectSpatial analysisen_US
dc.titleExploring Associations Between Residential Location and Breast Cancer Incidence in a Case-Control Studyen_US
dc.typeArticleen_US
dc.identifier.pmid12003750en_US
dc.identifier.pmcid1240835en_US


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