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dc.contributor.authorNelson, Jessica W.en_US
dc.contributor.authorHatch, Elizabeth E.en_US
dc.contributor.authorWebster, Thomas F.en_US
dc.date.accessioned2012-01-09T14:34:18Z
dc.date.available2012-01-09T14:34:18Z
dc.date.issued2010-02
dc.identifier.citationNelson, Jessica W., Elizabeth E. Hatch, Thomas F. Webster. "Exposure to Polyfluoroalkyl Chemicals and Cholesterol, Body Weight, and Insulin Resistance in the General U.S. Population" Environmental Health Perspectives 118 (2): 197-202. (2009)
dc.identifier.issn1552-9924
dc.identifier.urihttps://hdl.handle.net/2144/2779
dc.description.abstractBACKGROUND. Polyfluoroalkyl chemicals (PFCs) are used commonly in commercial applications and are detected in humans and the environment worldwide. Concern has been raised that they may disrupt lipid and weight regulation. OBJECTIVES. We investigated the relationship between PFC serum concentrations and lipid and weight outcomes in a large publicly available data set. METHODS. We analyzed data from the 2003-2004 National Health and Nutrition Examination Survey (NHANES) for participants 12-80 years of age. Using linear regression to control for covariates, we studied the association between serum concentrations of perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorooctane sulfonic acid (PFOS), and perfluorohexane sulfonic acid (PFHxS) and measures of cholesterol, body size, and insulin resistance. RESULTS. We observed a positive association between concentrations of PFOS, PFOA, and PFNA and total and non-high-density cholesterol. We found the opposite for PFHxS. Those in the highest quartile of PFOS exposure had total cholesterol levels 13.4 mg/dL [95% confidence interval (CI), 3.8-23.0] higher than those in the lowest quartile. For PFOA, PFNA, and PFHxS, effect estimates were 9.8 (95% CI, -0.2 to 19.7), 13.9 (95% CI, 1.9-25.9), and -7.0 (95% CI, -13.2 to -0.8), respectively. A similar pattern emerged when exposures were modeled continuously. We saw little evidence of a consistent association with body size or insulin resistance. CONCLUSIONS. This exploratory cross-sectional study is consistent with other epidemiologic studies in finding a positive association between PFOS and PFOA and cholesterol, despite much lower exposures in NHANES. Results for PFNA and PFHxS are novel, emphasizing the need to study PFCs other than PFOS and PFOA.en_US
dc.description.sponsorshipNational Institute of Environmental Health Sciences (R21ES013724, T32ES014562)en_US
dc.language.isoen
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.rightsThis is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.en_US
dc.subjectBody mass indexen_US
dc.subjectCholesterolen_US
dc.subjectInsulin resistanceen_US
dc.subjectNational Health and Nutrition Examination Survey (NHANES)en_US
dc.subjectPerfluorononanoic acid (PFNA)en_US
dc.subjectPerfluorohexane sulfonic acid (PFHxS)en_US
dc.subjectPerfluorooctane sulfonic acid (PFOS)en_US
dc.subjectPerfluorooctanoic acid (PFOA)en_US
dc.subjectPolyfluoroalkyl chemicals (PFCs)en_US
dc.subjectWaist circumferenceen_US
dc.titleExposure to Polyfluoroalkyl Chemicals and Cholesterol, Body Weight, and Insulin Resistance in the General U.S. Populationen_US
dc.typeArticleen_US
dc.identifier.doi10.1289/ehp.0901165
dc.identifier.pmid20123614
dc.identifier.pmcid2831917


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