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dc.contributor.authorJohns, Margaret Annen_US
dc.date.accessioned2018-04-05T17:17:46Z
dc.date.available2018-04-05T17:17:46Z
dc.date.issued1962
dc.date.submitted1962
dc.identifier.otherb14565638
dc.identifier.urihttps://hdl.handle.net/2144/28048
dc.descriptionThesis (M.A.)--Boston Universityen_US
dc.description.abstractSince the discovery of VI antigen by Felix and Pitt in 1934 (The Lancet, 2:186, 1934), investigators have attempted to isolate, purify and characterize this antigen. Antisera against purified VI antigens would prove a valuable tool for studying the effects of purification on the antigenic molecule. Purified Vi antigen, however, has proven to be a hapten in rabbits with one exception. Landy and Webster's Vi preparation was immunogenic for rabbits as well as for mice (J. Immunol., 69:143, 1952) but the preparations of Ashida (Japan. J. Exper. Med., 20:181, 1949), and of Baker, et al (J. Immunol., 83:687, 1959) were non-immunogenic although Baker's preparation immunized mice and man. Landy and Webster, however, observed that more of their preparation than of whole organisms was necessary to immunize rabbits to an equal degree [TRUNCATED]en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.rightsBased on investigation of the BU Libraries' staff, this work is free of known copyright restrictions.en_US
dc.subjectVI antigensen_US
dc.subjectImmunizationen_US
dc.titleImmunogenicity of the VI antigenen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameMaster of Artsen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMicrobiologyen_US
etd.degree.grantorBoston Universityen_US


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