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dc.contributor.authorMeck, Warren H.en_US
dc.contributor.authorWilliams, Christina L.en_US
dc.contributor.authorCermak, Jennifer Marieen_US
dc.contributor.authorBlusztajn, Jan Krzysztofen_US
dc.date.accessioned2012-01-09T16:04:52Z
dc.date.available2012-01-09T16:04:52Z
dc.date.copyright2008
dc.date.issued2008-05-03
dc.identifier.citationMeck, Warren H., Christina L. Williams, Jennifer Marie Cermak, Jan Krzysztof Blusztajn. "Developmental Periods of Choline Sensitivity Provide an Ontogenetic Mechanism for Regulating Memory Capacity and Age-Related Dementia" Frontiers in Integrative Neuroscience 1 (2008)
dc.identifier.issn1662-5145
dc.identifier.urihttps://hdl.handle.net/2144/2846
dc.description.abstractIn order to determine brain and behavioral sensitivity of nutrients that may serve as inductive signals during early development, we altered choline availability to rats during 7 time frames spanning embryonic day (ED) 6 through postnatal day (PD) 75 and examined spatial memory ability in the perinatally-treated adults. Two sensitive periods were identified, ED 12-17 and PD 16-30, during which choline supplementation facilitated spatial memory and produced increases in dendritic spine density in CA1 and dentate gyrus (DG) regions of the hippocampus while also changing the dendritic fields of DG granule cells. Moreover, choline supplementation during ED 12-17 only, prevented the memory decline normally observed in aged rats. These behavioral changes were strongly correlated with the acetylcholine (ACh) content of hippocampal slices following stimulated release. Our data demonstrate that the availability of choline during critical periods of brain development influences cognitive performance in adulthood and old age, and emphasize the importance of perinatal nutrition for successful cognitive aging.en_US
dc.description.sponsorshipUnited States National Institute of Aging (AG09525)en_US
dc.language.isoen
dc.publisherFrontiers Research Foundationen_US
dc.rightsCopyright 2008 Meck, Williams, Cermak and Blusztajn. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.en_US
dc.rights.urihttp://www.frontiersin.org/licenseagreement
dc.subjectSpatial memoryen_US
dc.subjectCognitive agingen_US
dc.subjectHippocampusen_US
dc.subjectPerinatal nutritionen_US
dc.subjectNeural plasticityen_US
dc.subjectEpigeneticsen_US
dc.subjectGene expressionen_US
dc.titleDevelopmental Periods of Choline Sensitivity Provide an Ontogenetic Mechanism for Regulating Memory Capacity and Age-Related Dementiaen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/neuro.07.007.2007
dc.identifier.pmid18958235
dc.identifier.pmcid2526009


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