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dc.contributor.authorFurukawa, Toshi A.en_US
dc.contributor.authorWeitz, Erica S.en_US
dc.contributor.authorTanaka, Shiroen_US
dc.contributor.authorHollon, Steven D.en_US
dc.contributor.authorHofmann, Stefan G.en_US
dc.contributor.authorAndersson, Gerharden_US
dc.contributor.authorTwisk, Josen_US
dc.contributor.authorDeRubeis, Robert J.en_US
dc.contributor.authorDimidjian, Sonaen_US
dc.contributor.authorHegerl, Ulrichen_US
dc.contributor.authorMergl, Rolanden_US
dc.contributor.authorJarrett, Robin B.en_US
dc.contributor.authorVittengl, Jeffrey R.en_US
dc.contributor.authorWatanabe, Norioen_US
dc.contributor.authorCuijpers, Pimen_US
dc.coverage.spatialEnglanden_US
dc.date2016-09-10
dc.date.accessioned2018-04-25T17:21:38Z
dc.date.available2018-04-25T17:21:38Z
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/28104735
dc.identifier.citationToshi A Furukawa, Erica S Weitz, Shiro Tanaka, Steven D Hollon, Stefan G Hofmann, Gerhard Andersson, Jos Twisk, Robert J DeRubeis, Sona Dimidjian, Ulrich Hegerl, Roland Mergl, Robin B Jarrett, Jeffrey R Vittengl, Norio Watanabe, Pim Cuijpers. "Initial severity of depression and efficacy of cognitive-behavioural therapy: individual-participant data meta-analysis of pill-placebo-controlled trials.." Br J Psychiatry, Volume 210, Issue 3, pp. 190 - 196.
dc.identifier.issn1472-1465
dc.identifier.urihttps://hdl.handle.net/2144/28480
dc.description.abstractBACKGROUND: The influence of baseline severity has been examined for antidepressant medications but has not been studied properly for cognitive-behavioural therapy (CBT) in comparison with pill placebo. AIMS: To synthesise evidence regarding the influence of initial severity on efficacy of CBT from all randomised controlled trials (RCTs) in which CBT, in face-to-face individual or group format, was compared with pill-placebo control in adults with major depression. METHOD: A systematic review and an individual-participant data meta-analysis using mixed models that included trial effects as random effects. We used multiple imputation to handle missing data. RESULTS: We identified five RCTs, and we were given access to individual-level data (n = 509) for all five. The analyses revealed that the difference in changes in Hamilton Rating Scale for Depression between CBT and pill placebo was not influenced by baseline severity (interaction P = 0.43). Removing the non-significant interaction term from the model, the difference between CBT and pill placebo was a standardised mean difference of -0.22 (95% CI -0.42 to -0.02, P = 0.03, I2 = 0%). CONCLUSIONS: Patients suffering from major depression can expect as much benefit from CBT across the wide range of baseline severity. This finding can help inform individualised treatment decisions by patients and their clinicians.en_US
dc.description.sponsorshipR01 MH060998 - NIMH NIH HHS; R34 MH086668 - NIMH NIH HHS; R01 AT007257 - NCCIH NIH HHS; R21 MH101567 - NIMH NIH HHS; K02 MH001697 - NIMH NIH HHS; R01 MH060713 - NIMH NIH HHS; R34 MH099311 - NIMH NIH HHS; R21 MH102646 - NIMH NIH HHS; K23 MH100259 - NIMH NIH HHS; R01 MH099021 - NIMH NIH HHSen_US
dc.format.extent190 - 196en_US
dc.languageeng
dc.relation.ispartofBr J Psychiatry
dc.rightsCopyright © The Royal College of Psychiatrists 2017.en_US
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectPsychiatryen_US
dc.subjectPatient dataen_US
dc.subjectAnti-depressantsen_US
dc.subjectPsychotherapy trialsen_US
dc.subjectComparative benefitsen_US
dc.subjectSystematic reviewsen_US
dc.subjectAdult depressionen_US
dc.subjectWaiting listen_US
dc.subjectPharmacotherapyen_US
dc.subjectCognitive therapyen_US
dc.subjectDepressive disorder, Majoren_US
dc.subjectHumansen_US
dc.subjectOutcome assessment (Health care)en_US
dc.subjectRandomized controlled trialsen_US
dc.subjectSeverity of Illness Indexen_US
dc.subjectMedical and health sciencesen_US
dc.subjectPsychology and cognitive aciencesen_US
dc.subjectPsychiatryen_US
dc.titleInitial severity of depression and efficacy of cognitive-behavioural therapy: individual-participant data meta-analysis of pill-placebo-controlled trialsen_US
dc.typeArticleen_US
dc.identifier.doi10.1192/bjp.bp.116.187773
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Psychological & Brain Sciencesen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0002-3548-9681 (Hofmann, Stefan G)


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