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  • viSNE fine-tuning enables better resolution of cell populations 

    Belkina, Anna; Ciccolella, Chris; Snyder-Cappione, Jennifer (2017-06-09)
    t-Distributed Stochastic Neighbor Embedding (t-SNE or viSNE) is a dimensionality reduction algorithm that allows visualization of complex high-dimensional cytometry data as a two-dimensional distribution or " map ". These ...
  • Role of Fas and Treg cells in fracture healing as characterized in the Fas‐deficient (lpr) mouse model of lupus 

    Al‐Sebaei, Maisa O.; Daukss, Dana M.; Belkina, Anna C.; Kakar, Sanjeev; Wigner, Nathan A.; Cusher, Daniel; Graves, Dana; Einhorn, Thomas; Morgan, Elise; Gerstenfeld, Louis C. (Journal of Bone and Mineral Research, 2014-05-19)
    Previous studies showed that loss of tumor necrosis factora (TNFa) signaling delayed fracture healing by delaying chondrocyte apoptosis and cartilage resorption. Mechanistic studies showed that TNFa induced Fas expression ...
  • Epithelial cell–derived secreted and transmembrane 1a signals to activated neutrophils during pneumococcal pneumonia 

    Kamata, Hirofumi; Yamamoto, Kazuko; Wasserman, Gregory A.; Zabinski, Mary C.; Yuen, Constance K.; Lung, Wing Yi; Gower, Adam C.; Belkina, Anna C.; Ramirez, Maria I.; Deng, Jane C.; Quinton, Lee J.; Jones, Matthew R.; Mizgerd, Joseph P. (American journal of respiratory cell and molecular biology, 2016-04-11)
    Airway epithelial cell responses are critical to the outcome of lung infection. In this study, we aimed to identify unique contributions of epithelial cells during lung infection. To differentiate genes induced selectively ...
  • Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B cell development 

    Lentucci, Claudia; Belkina, Anna C.; Cederquist, Carly T.; Chan, Michelle; Johnson, Holly E.; Prasad, Sherry; Lopacinski, Amanda; Nikolajczyk, Barbara S.; Monti, Stefano; Snyder-Cappione, Jennifer; Tanasa, Bogdan; Cardamone, M. Dafne; Perissi, Valentina (The Journal of Biological Chemistry, 2016-12-30)
    Non-proteolytic ubiquitin signaling mediated by Lys63 ubiquitin chains plays a critical role in multiple pathways that are key to the development and activation of immune cells. Our previous work indicates that GPS2 ...
  • Abstract 803: Targeting β-catenin/CBP signaling in OSCC 

    Alamoud, Khalid; Sadykov, Khikmet; Kartha, Vinay; Monti, Stefano; Belkina, Anna; Snyder-Cappione, Jennifer; Pai, Sara; Kukuruzinska, Maria (AACR Publications, 2017-07)
    OBJECTIVES: Oral squamous cell carcinoma (OSCC) is an aggressive malignancy characterized by molecular heterogeneity and locoregional spread associated with high morbidity. Aggressive cancers are thought to arise from ...
  • Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy 

    Woolf, N.; Pearson, B.E.; Bondzie, P.A.; Meyer, R.D.; Lavaei, M.; Belkina, A.C.; Rahimi, N. (Nature Publishing Group, 2017-09-18)
    Adhesion to extracellular matrix (ECM) is crucially important for survival of normal epithelial cells as detachment from ECM triggers specific apoptosis known as anoikis. As tumor cells lose the requirement for anchorage ...
  • Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) Is related to a diminished CD69 and TGFβ expression 

    Radstake, Timothy R. D. J.; Van Bon, Lenny; Broen, Jasper; Wenink, Mark; Santegoets, Kim; Deng, Yanhui; Hussaini, Anila; Simms, Robert; Cruikshank, William W.; Lafyatis, Robert (Public Library of Science, 2009-6-22)
    BACKGROUND. Regulatory T cells (Tregs) are essential in the control of tolerance. Evidence implicates Tregs in human autoimmune conditions. Here we investigated their role in systemic sclerosis (SSc). METHODS/PRINCIPAL ...
  • The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFβ and IFNϒ distinguishes SSc phenotypes 

    Radstake, Timothy R. D. J.; Van Bon, Lenny; Broen, Jasper; Hussiani, Anila; Hesselstrand, Roger; Wuttge, Dirk M.; Deng, Yanhui; Simms, Robbert; Lubberts, Erik; Lafyatis, Robert (Public Library of Science, 2009-6-17)
    BACKGROUND. Systemic sclerosis (SSc) is an autoimmune disease where controversy on Th1/Th2 balance dominates. We investigated whether the recently discovered Th17 pattern was present in SSc. METHODOLOGY AND PRINCIPAL ...