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    •   OpenBU
    • School of Medicine
    • Clinical Science
    • Department of Medicine
    • MED: Medicine Papers
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    Toll-Like Receptors and Innate Immune Responses in Systemic Lupus Erythematosus

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    Date Issued
    2007-11-29
    Related DOI
    10.1186/ar2321
    Author
    Lafyatis, Robert
    Marshak-Rothstein, Ann
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    Permanent Link
    https://hdl.handle.net/2144/2876
    Citation
    Lafyatis, Robert, Ann Marshak-Rothstein. "Toll-like receptors and innate immune responses in systemic lupus erythematosus" Arthritis Research & Therapy 9(6):222. (2007)
    Abstract
    A series of discoveries over the past several years has provided a new paradigm for understanding autoimmunity in systemic lupus erythematosus. The discoveries of pattern recognition receptors and of how these receptors can be recruited into autoimmune responses underpin this paradigm. The implications of these observations continue to unfold with ongoing investigation into the range and specificity of pattern recognition receptors, into how immune complexes containing nucleic acids trigger these receptors, into how endogenous macromolecular 'danger signals' stimulate innate immune responses, and into the effect of pattern recognition receptor activation on various cell types in initiating and perpetuating autoimmunity. The development of clinical trials using therapeutic agents that target components of the innate immune system suggests that these advances may soon culminate in new medications for treating patients with systemic lupus erythematosus.
    Rights
    Copyright 2007 BioMed Central Ltd
    Collections
    • MED: Medicine Papers [229]
    • MED: Microbiology Papers [15]

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