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dc.contributor.authorQi, Chaoen_US
dc.contributor.authorWang, Wenyuen_US
dc.contributor.authorReichl, Kyle D.en_US
dc.contributor.authorMcNeely, Jamesen_US
dc.contributor.authorPorco, John A.en_US
dc.coverage.spatialGermanyen_US
dc.date.accessioned2018-05-14T13:23:12Z
dc.date.available2018-05-14T13:23:12Z
dc.date.issued2018-02-19
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/29318760
dc.identifier.citationChao Qi, Wenyu Wang, Kyle D Reichl, James McNeely, John A Porco. 2018. "Total Synthesis of Aurofusarin: Studies on the Atropisomeric Stability of Bis-Naphthoquinones.." Angew Chem Int Ed Engl, Volume 57, Issue 8, pp. 2101 - 2104.
dc.identifier.issn1521-3773
dc.identifier.urihttps://hdl.handle.net/2144/28889
dc.description.abstractAn efficient annulation involving pyrone addition to a quinone and Dieckmann condensation was developed for rapid assembly of a γ-naphthopyrone monomeric precursor to the bis-naphthoquinone natural product aurofusarin. Dimerization was achieved through PdII -catalyzed dehydrogenative coupling. Further studies employing asymmetric nucleophilic epoxidation indicate that the atropisomers of aurofusarin and derivatives are not configurationally stable at ambient temperature.en_US
dc.description.sponsorshipR24 GM111625 - NIGMS NIH HHS; R35 GM118173 - NIGMS NIH HHSen_US
dc.format.extent2101 - 2104en_US
dc.languageeng
dc.relation.ispartofAngew Chem Int Ed Engl
dc.subjectScience & technologyen_US
dc.subjectPhysical sciencesen_US
dc.subjectChemistryen_US
dc.subjectAnnulationen_US
dc.subjectAxial chiralityen_US
dc.subjectEpoxidationen_US
dc.subjectDehydrogenative couplingen_US
dc.subjectNaphthoquinonesen_US
dc.subjectFungien_US
dc.subjectBiosynthesisen_US
dc.subjectChemical sciencesen_US
dc.subjectOrganic chemistryen_US
dc.titleTotal synthesis of aurofusarin: studies on the atropisomeric stability of bis-naphthoquinonesen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/anie.201711535
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Chemistryen_US
pubs.publication-statusPublisheden_US


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