Search for Genetic Factors Predisposing to Atherogenic Dyslipidemia
Yip, Agustin G.
Panhuysen, Carolien I.
Farrer, Lindsay A.
Wyszynski, Diego F.
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CitationYip, Agustin G, Qianli Ma, Marsha Wilcox, Carolien I Panhuysen, John Farrell, Lindsay A Farrer, Diego F Wyszynski. "Search for genetic factors predisposing to atherogenic dyslipidemia" BMC Genetics 4(Suppl 1):S100. (2003)
BACKGROUND. Atherogenic dyslipidemia (AD) is a common feature in persons with premature coronary heart disease. While several linkage studies have been carried out to dissect the genetic etiology of lipid levels, few have investigated the AD lipid triad comprising elevated serum triglyceride, small low density lipoprotein (LDL) particles, and reduced high density lipoprotein (HDL) cholesterol levels. Here we report the results of a whole-genome screen for AD using the Framingham Heart Study population. RESULTS. Our analyses provide some evidence for linkage to AD on chromosomes 1q31, 3q29, 10q26, 14p12, 14q13, 16q24, 18p11, and 19q13. CONCLUSION. AD susceptibility is modulated by multiple genes in different chromosomes. Our study confirms results from other populations and suggests new areas of potential importance.
RightsCopyright 2003 Yip et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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