Genome-Wide Screen for Heavy Alcohol Consumption
Wyszynski, Diego F.
Panhuysen, Carolien I.
Yip, Agustin G.
Farrer, Lindsay A.
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CitationWyszynski, Diego F, Carolien I Panhuysen, Qianli Ma, Agustin G Yip, Marsha Wilcox, Porat Erlich, Lindsay A Farrer. "Genome-wide screen for heavy alcohol consumption" BMC Genetics 4(Suppl 1):S106. (2003)
BACKGROUND. To find specific genes predisposing to heavy alcohol consumption (self-reported consumption of 24 grams or more of alcohol per day among men and 12 grams or more among women), we studied 330 families collected by the Framingham Heart Study made available to participants in the Genetic Analysis Workshop 13 (GAW13). RESULTS. Parametric and nonparametric methods of linkage analysis were used. No significant evidence of linkage was found; however, weak signals were identified in several chromosomal regions, including 1p22, 4q12, 4q25, and 11q24, which are in the vicinity of those reported in other similar studies. CONCLUSION. Our study did not reveal significant evidence of linkage to heavy alcohol use; however, we found weak confirmation of studies carried out in other populations.
RightsCopyright 2003 Wyszynski et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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