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dc.contributor.authorSvardal, Hannesen_US
dc.contributor.authorJasinska, Anna J.en_US
dc.contributor.authorApetrei, Cristianen_US
dc.contributor.authorCoppola, Giovannien_US
dc.contributor.authorHuang, Yuen_US
dc.contributor.authorSchmitt, Christopher A.en_US
dc.contributor.authorJacquelin, Beatriceen_US
dc.contributor.authorRamensky, Vasilyen_US
dc.contributor.authorMüller-Trutwin, Michaelaen_US
dc.contributor.authorAntonio, Martinen_US
dc.contributor.authorWeinstock, Georgeen_US
dc.contributor.authorGrobler, J. Paulen_US
dc.contributor.authorDewar, Kenen_US
dc.contributor.authorWilson, Richard K.en_US
dc.contributor.authorTurner, Trudy R.en_US
dc.contributor.authorWarren, Wesley C.en_US
dc.contributor.authorFreimer, Nelson B.en_US
dc.contributor.authorNordborg, Magnusen_US
dc.coverage.spatialUnited Statesen_US
dc.date2017-09-27
dc.date.accessioned2018-05-14T16:55:35Z
dc.date.available2018-05-14T16:55:35Z
dc.date.issued2017-12
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/29083404
dc.identifier.citationHannes Svardal, Anna J Jasinska, Cristian Apetrei, Giovanni Coppola, Yu Huang, Christopher A Schmitt, Beatrice Jacquelin, Vasily Ramensky, Michaela Müller-Trutwin, Martin Antonio, George Weinstock, J Paul Grobler, Ken Dewar, Richard K Wilson, Trudy R Turner, Wesley C Warren, Nelson B Freimer, Magnus Nordborg. 2017. "Ancient hybridization and strong adaptation to viruses across African vervet monkey populations.." Nat Genet, Volume 49, Issue 12, pp. 1705 - 1713.
dc.identifier.issn1546-1718
dc.identifier.urihttps://hdl.handle.net/2144/28907
dc.description.abstractVervet monkeys are among the most widely distributed nonhuman primates, show considerable phenotypic diversity, and have long been an important biomedical model for a variety of human diseases and in vaccine research. Using whole-genome sequencing data from 163 vervets sampled from across Africa and the Caribbean, we find high diversity within and between taxa and clear evidence that taxonomic divergence was reticulate rather than following a simple branching pattern. A scan for diversifying selection across taxa identifies strong and highly polygenic selection signals affecting viral processes. Furthermore, selection scores are elevated in genes whose human orthologs interact with HIV and in genes that show a response to experimental simian immunodeficiency virus (SIV) infection in vervet monkeys but not in rhesus macaques, suggesting that part of the signal reflects taxon-specific adaptation to SIV.en_US
dc.description.sponsorshipR01 OD010980 - NIH HHS; R01 AI119346 - NIAID NIH HHS; P30 NS062691 - NINDS NIH HHS; R01 RR016300 - NCRR NIH HHS; R24 OD010976 - NIH HHSen_US
dc.format.extentp. 1705 - 1713en_US
dc.languageeng
dc.relation.ispartofNat Genet
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectGenetics & heredityen_US
dc.subjectSIV infectionen_US
dc.subjectSooty mangabeyen_US
dc.subjectRhesus macaquesen_US
dc.subjectDNAen_US
dc.subjectAdaptation, physiologicalen_US
dc.subjectAfricaen_US
dc.subjectAnimalsen_US
dc.subjectCD4-Positive T-Lymphocytesen_US
dc.subjectCercopithecus aethiopsen_US
dc.subjectGene expression profilingen_US
dc.subjectGene ontologyen_US
dc.subjectGene regulatory networksen_US
dc.subjectGenetic variationen_US
dc.subjectHost-pathogen interactionsen_US
dc.subjectHybridization, geneticen_US
dc.subjectMacaca mulattaen_US
dc.subjectPhylogenyen_US
dc.subjectSimian Acquired Immunodeficiency Syndromeen_US
dc.subjectSimian immunodeficiency virusen_US
dc.subjectSpecies apecificityen_US
dc.subjectCD4-Positive T-Lymphocytesen_US
dc.subjectMedical and health sciencesen_US
dc.subjectBiological sciencesen_US
dc.subjectDevelopmental biologyen_US
dc.titleAncient hybridization and strong adaptation to viruses across African vervet monkey populationsen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/ng.3980
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Anthropologyen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0003-2143-9226 (Schmitt, Christopher A)


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