Show simple item record

dc.contributor.authorGao, Yuanen_US
dc.contributor.authorBudlong, Carlen_US
dc.contributor.authorDurlacher, Emilyen_US
dc.contributor.authorDavison, Ian G.en_US
dc.coverage.spatialEnglanden_US
dc.date2017-06-13
dc.date.accessioned2018-05-14T17:35:30Z
dc.date.available2018-05-14T17:35:30Z
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/28621665
dc.identifier.citationYuan Gao, Carl Budlong, Emily Durlacher, Ian G Davison. "Neural mechanisms of social learning in the female mouse.." eLife 2017;6:e25421 DOI: 10.7554/eLife.25421
dc.identifier.issn2050-084X
dc.identifier.urihttps://hdl.handle.net/2144/28913
dc.description.abstractSocial interactions are often powerful drivers of learning. In female mice, mating creates a long-lasting sensory memory for the pheromones of the stud male that alters neuroendocrine responses to his chemosignals for many weeks. The cellular and synaptic correlates of pheromonal learning, however, remain unclear. We examined local circuit changes in the accessory olfactory bulb (AOB) using targeted ex vivo recordings of mating-activated neurons tagged with a fluorescent reporter. Imprinting led to striking plasticity in the intrinsic membrane excitability of projection neurons (mitral cells, MCs) that dramatically curtailed their responsiveness, suggesting a novel cellular substrate for pheromonal learning. Plasticity was selectively expressed in the MC ensembles activated by the stud male, consistent with formation of memories for specific individuals. Finally, MC excitability gained atypical activity-dependence whose slow dynamics strongly attenuated firing on timescales of several minutes. This unusual form of AOB plasticity may act to filter sustained or repetitive sensory signals.en_US
dc.description.sponsorshipR21 DC013894 - NIDCD NIH HHSen_US
dc.languageeng
dc.relation.ispartofElife
dc.rightsCopyright: © 2017, Gao et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectScience & technologyen_US
dc.subjectLife Sciences & biomedicineen_US
dc.subjectBiologyen_US
dc.subjectElectrophysiologyen_US
dc.subjectLearningen_US
dc.subjectMouseen_US
dc.subjectNeuroscienceen_US
dc.subjectOlfactoryen_US
dc.subjectPheromoneen_US
dc.subjectSocialen_US
dc.subjectAnimalsen_US
dc.subjectFemaleen_US
dc.subjectMiceen_US
dc.subjectNeuronsen_US
dc.subjectOlfactory bulben_US
dc.subjectOlfactory perceptionen_US
dc.subjectPheromonesen_US
dc.subjectSmellen_US
dc.subjectSocial learningen_US
dc.titleNeural mechanisms of social learning in the female mouseen_US
dc.typeArticleen_US
dc.identifier.doi10.7554/eLife.25421
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Biologyen_US
pubs.publication-statusPublished onlineen_US


This item appears in the following Collection(s)

Show simple item record

Copyright: © 2017, Gao et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Except where otherwise noted, this item's license is described as Copyright: © 2017, Gao et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.