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dc.contributor.authorMa, Qianlien_US
dc.contributor.authorYu, Yien_US
dc.contributor.authorMeng, Yanen_US
dc.contributor.authorFarrell, Johnen_US
dc.contributor.authorFarrer, Lindsay A.en_US
dc.contributor.authorWilcox, Marsha A.en_US
dc.date.accessioned2012-01-09T20:53:15Z
dc.date.available2012-01-09T20:53:15Z
dc.date.copyright2005
dc.date.issued2005-12-30
dc.identifier.citationMa, Qianli, Yi Yu, Yan Meng, John Farrell, Lindsay A Farrer, Marsha A Wilcox. "Genome-wide linkage analysis for alcohol dependence: a comparison between single-nucleotide polymorphism and microsatellite marker assays" BMC Genetics 6(Suppl 1):S8. (2005)
dc.identifier.issn1471-2156
dc.identifier.urihttps://hdl.handle.net/2144/2895
dc.description.abstractBoth theoretical and applied studies have proven that the utility of single nucleotide polymorphism (SNP) markers in linkage analysis is more powerful and cost-effective than current microsatellite marker assays. Here we performed a whole-genome scan on 115 White, non-Hispanic families segregating for alcohol dependence, using one 10.3-cM microsatellite marker set and two SNP data sets (0.33-cM, 0.78-cM spacing). Two definitions of alcohol dependence (ALDX1 and ALDX2) were used. Our multipoint nonparametric linkage analysis found alcoholism was nominal linked to 12 genomic regions. The linkage peaks obtained by using the microsatellite marker set and the two SNP sets had a high degree of correspondence in general, but the microsatellite marker set was insufficient to detect some nominal linkage peaks. The presence of linkage disequilibrium between markers did not significantly affect the results. Across the entire genome, SNP datasets had a much higher average linkage information content (0.33 cM: 0.93, 0.78 cM: 0.91) than did microsatellite marker set (0.57). The linkage peaks obtained through two SNP datasets were very similar with some minor differences. We conclude that genome-wide linkage analysis by using approximately 5,000 SNP markers evenly distributed across the human genome is sufficient and might be more powerful than current 10-cM microsatellite marker assays.en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2005 Ma et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.titleGenome-Wide Linkage Analysis for Alcohol Dependence: A Comparison between Single-Nucleotide Polymorphism and Microsatellite Marker Assaysen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1471-2156-6-S1-S8
dc.identifier.pmid16451694
dc.identifier.pmcid1866701


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Copyright 2005 Ma et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2005 Ma et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.