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dc.contributor.authorDibble, Leland E.en_US
dc.contributor.authorCavanaugh, James T.en_US
dc.contributor.authorEarhart, Gammon M.en_US
dc.contributor.authorEllis, Terry D.en_US
dc.contributor.authorFord, Matthew P.en_US
dc.contributor.authorForeman, Kenneth B.en_US
dc.coverage.spatialEnglanden_US
dc.date2010-11-03
dc.date.accessioned2018-06-12T19:48:33Z
dc.date.available2018-06-12T19:48:33Z
dc.date.issued2010-11-03
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/21047426
dc.identifier.citationLeland E Dibble, James T Cavanaugh, Gammon M Earhart, Terry D Ellis, Matthew P Ford, Kenneth B Foreman. 2010. "Charting the progression of disability in Parkinson disease: study protocol for a prospective longitudinal cohort study.." BMC Neurol, Volume 10:110.
dc.identifier.issn1471-2377
dc.identifier.urihttps://hdl.handle.net/2144/29284
dc.description.abstractBACKGROUND: People with Parkinson disease (PD), even in the presence of symptomatic relief from medical, surgical, and rehabilitative interventions, face a persistent worsening of disability. This disability is characterized by diminished quality of life, reduced functional mobility, declining performance in activities of daily living and worsening neurological impairments. While evidence has emerged supporting the clinically meaningful benefits of short-term exercise programs on these underlying factors, assertions regarding the effects of sustained programs of exercise and physical activity on the trajectory of disablement in PD are made in the absence of direct evidence. Indeed, the natural decline in quality of life and functional mobility in people diagnosed with PD is poorly understood. Moreover, outcome measures commonly used in clinical exercise trials typically do not capture the full spectrum of disability as defined by the World Health Organization (WHO). METHODS/DESIGN: The objective of this multicenter prospective study will be to examine the 2-year trajectory of disablement in a cohort of persons with PD. Two hundred sixty participants will be recruited to produce an expected final sample size of 150 individuals. Participants will be included if they are greater than 40 years of age, have a neurologist confirmed diagnosis of idiopathic PD, and are at Hoehn and Yahr stages 1 through 4. Data will be collected every 6 months during the study period. Primary outcome measures reflecting a broad spectrum of disablement will include, but will not be limited to, MDS-UPDRS, Timed Up and Go, Berg Balance Test, Nine Hole Peg Test, PDQ-39, and directly monitored ambulatory activity. Self-reported exercise and physical activity data also will be recorded. Statistical analyses will be used to characterize the trajectory of disablement and examine the influence of its underlying contributing factors. DISCUSSION: Tertiary prevention is an important component of contemporary healthcare for individuals living with degenerative disease. For individuals with PD, there is growing recognition that exercise and/or physical activity efforts to slow the rate of functional mobility decline, in particular, may be critical for optimizing quality of life. By describing the natural trajectory of disablement, exercise habits, and physical activity in a cohort of persons with PD, this investigation will establish an important foundation for future intervention research. Specifically, through the evaluation of the influence of sustained exercise and physical activity on disablement, the study will serve as a preliminary step toward developing a randomized controlled trial of long-term exercise in persons with PD.en_US
dc.format.extent110en_US
dc.languageeng
dc.relation.ispartofBMC Neurol
dc.rights© Dibble et al; licensee BioMed Central Ltd. 2010 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectClinical neurologyen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectQuality of lifeen_US
dc.subjectFunctional Gait Assessmenten_US
dc.subjectBerg Balance Scaleen_US
dc.subjectElderly phaseen_US
dc.subjectAdulten_US
dc.subjectCohort studiesen_US
dc.subjectDisease progressionen_US
dc.subjectHumansen_US
dc.subjectLongitudinal studiesen_US
dc.subjectMiddle ageden_US
dc.subjectParkinson diseaseen_US
dc.subjectResearch designen_US
dc.subjectSeverity of Illness Indexen_US
dc.subjectCognitive scienceen_US
dc.titleCharting the progression of disability in Parkinson disease: study protocol for a prospective longitudinal cohort studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1471-2377-10-110
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Physical Therapy and Athletic Trainingen_US
pubs.publication-statusPublished onlineen_US


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© Dibble et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as © Dibble et al; licensee BioMed Central Ltd. 2010 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.