Functional competence of intact and transplanted endocrine pancreas in the normal and alloxan diabetic golden hamster
Sak, Matthew Frank
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Functional competence of intact pancreas and neonatal pancreatic implants was determined in normal and alloxan diabetic Golden Hamsters by measurement of the ability to release insulin-like activity (ILA) in vitro and in vivo as bioassayed by the rat epididymal fat ped technique. Islets were determined to be functionally competent before birth. ILA was released in vitro prior to the second post-natal day when beta cells first showed definite granulation. By 30 days, beta cells showed mature granulation but with advancing age, they released less ILA. It is suggested that the corresponding development of exocrine pancreas results in proteolytic inactivation of ILA in vitro [TRUNCATED]
Thesis (Ph.D.)--Boston University
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