Boston University Libraries OpenBU
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    •   OpenBU
    • School of Medicine
    • Clinical Science
    • Department of Medicine
    • MED: Medicine Papers
    • View Item
    •   OpenBU
    • School of Medicine
    • Clinical Science
    • Department of Medicine
    • MED: Medicine Papers
    • View Item

    Development of an Acute and Highly Pathogenic Nonhuman Primate Model of Nipah Virus Infection

    Thumbnail
    Date Issued
    2010-5-18
    Publisher Version
    10.1371/journal.pone.0010690
    Author(s)
    Geisbert, Thomas W.
    Daddario-DiCaprio, Kathleen M.
    Hickey, Andrew C.
    Smith, Mark A.
    Chan, Yee-Peng
    Wang, Lin-Fa
    Mattapallil, Joseph J.
    Geisbert, Joan B.
    Bossart, Katharine N.
    Broder, Christopher C.
    Share to FacebookShare to TwitterShare by Email
    Export Citation
    Download to BibTex
    Download to EndNote/RefMan (RIS)
    Metadata
    Show full item record
    Permanent Link
    https://hdl.handle.net/2144/2978
    Citation (published version)
    Geisbert, Thomas W., Kathleen M. Daddario-DiCaprio, Andrew C. Hickey, Mark A. Smith, Yee-Peng Chan, Lin-Fa Wang, Joseph J. Mattapallil, Joan B. Geisbert, Katharine N. Bossart, Christopher C. Broder. "Development of an Acute and Highly Pathogenic Nonhuman Primate Model of Nipah Virus Infection" PLoS ONE 5(5): e10690. (2010)
    Abstract
    Nipah virus (NiV) is an enigmatic emerging pathogen that causes severe and often fatal neurologic and/or respiratory disease in both animals and humans. Amongst people, case fatality rates range between 40 and 75 percent and there are no vaccines or treatments approved for human use. Guinea pigs, hamsters, cats, ferrets, pigs and most recently squirrel monkeys (New World monkey) have been evaluated as animal models of human NiV infection, and with the exception of the ferret, no model recapitulates all aspects of NiV-mediated disease seen in humans. To identify a more viable nonhuman primate (NHP) model, we examined the pathogenesis of NiV in African green monkeys (AGM). Exposure of eight monkeys to NiV produced a severe systemic infection in all eight animals with seven of the animals succumbing to infection. Viral RNA was detected in the plasma of challenged animals and occurred in two of three subjects as a peak between days 7 and 21, providing the first clear demonstration of plasma-associated viremia in NiV experimentally infected animals and suggested a progressive infection that seeded multiple organs simultaneously from the initial site of virus replication. Unlike the cat, hamster and squirrel monkey models of NiV infection, severe respiratory pathology, neurological disease and generalized vasculitis all manifested in NiV-infected AGMs, providing an accurate reflection of what is observed in NiV-infected humans. Our findings demonstrate the first consistent and highly pathogenic NHP model of NiV infection, providing a new and critical platform in the evaluation and licensure of either passive and active immunization or therapeutic strategies for human use.
    Rights
    This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
    Collections
    • MED: Medicine Papers [241]
    • MED: Microbiology Papers [18]
    • National Emerging Infectious Diseases Laboratories Papers [4]


    Boston University
    Contact Us | Send Feedback | Help
     

     

    Browse

    All of OpenBUCommunities & CollectionsIssue DateAuthorsTitlesSubjectsThis CollectionIssue DateAuthorsTitlesSubjects

    Deposit Materials

    LoginNon-BU Registration

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Boston University
    Contact Us | Send Feedback | Help